Browse the latest research summaries in the field of brain injury for spinal cord injury patients and caregivers.
Showing 21-30 of 128 results
CNS Neurosci Ther, 2024 • May 11, 2024
TBI and SCI involve intricate pathological mechanisms, and the inflammatory response contributes significantly to secondary injury in TBI and SCI. This study examines the upstream and downstream pathw...
KEY FINDING: This study examines the upstream and downstream pathways involved in inflammation caused by TBI and SCI, including interleukins, T cells, NK cells, XCL1, XCR1+ dendritic cells, and interferon-gamma, describing their proinflammatory effect.
European Journal of Physical and Rehabilitation Medicine, 2023 • June 1, 2023
This study validated the Assessment of Participation and Executive Functions (A-PEX) as a tool for evaluating executive function deficits through actual participation in the inpatient rehabilitation c...
KEY FINDING: The A-PEX demonstrated excellent internal consistency, with Cronbach’s alpha coefficients ranging from 0.83 to 0.96 for its domains and scales.
Therapeutic Advances in Neurological Disorders, 2023 • February 14, 2023
This review provides an overview of locked-in syndrome (LiS), covering its anatomy, pathophysiology, treatments, quality of life, and ethical considerations. It discusses the different structures affe...
KEY FINDING: The review highlights the anatomical foundations of LiS and LiPS, discussing the structures in the pons, mesencephalon, and thalamus that can be affected. Damage to these areas can result in classical, complete, and incomplete LiS, as well as LiPS, which includes impairments of consciousness.
J Rehabil Med, 2023 • February 26, 2023
The aim of the current study was to use empirical data to explore and breakdown the utilization and cost components of formal and informal care provided to individuals following TBI and SCI sustained ...
KEY FINDING: Spinal cord injury (tetraplegia/ paraplegia) was significantly more expensive for both formal and informal care compared with traumatic brain injury.
Ann Neurol, 2023 • December 1, 2023
This study developed a 1-year functional dependency prediction model for patients with DoC after TBI using data from TBI-MS and TRACK-TBI. The model incorporates age, severity of neurological impairme...
KEY FINDING: A combination of variables (age, IVH, followed commands within 5 days of injury, and severity of functional and motor impairment at admission to rehabilitation) produces a well-calibrated estimate of the probability of functional dependency at 1-year.
Ann Rehabil Med, 2023 • October 1, 2023
This study investigated the epidemiology of patients with SCI alone and those with SCI+TBI. A significant difference in the AIS conversion rate between the two groups was found. The patient might have...
KEY FINDING: The study found that among 363 patients with T-SCI, 296 (81.5%) were males, and 67 (18.5%) were females, with an average age of 57.1 years.
Brain and Spine, 2023 • October 21, 2023
The study evaluated the incidence and impact of tandem neurotrauma in the UK using data from the TARN registry. The annual incidence of tandem neurotrauma increased significantly between 2008 and 2018...
KEY FINDING: The incidence of tandem neurotrauma increased tenfold between 2008 and 2018.
Heliyon, 2023 • November 8, 2023
This observational study aims to map and quantify physical activity patterns in patients admitted to brain injury rehabilitation using wearable activity trackers. The study will investigate factors as...
KEY FINDING: The primary objective of this study is to characterise mobility and physical activity levels in patients with moderate to severe acquired brain injury using four prespecified physical activity levels (physically active, physically sedentary, physically inactive, and sleep) at the early and late phases of hospital rehabilitation.
Neural Regeneration Research, 2024 • September 22, 2023
This study investigated the effects of repetitive blast-induced traumatic brain injury (bTBI) on epinephrine (Epi) levels in specific regions of the central nervous system (CNS) in rats. The present s...
KEY FINDING: Epinephrine levels were significantly decreased in the lumbar spinal cord tissues of bTBI animals compared to sham controls. Our results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age- and sex-matched sham controls.
Front. Hum. Neurosci., 2024 • February 20, 2024
This editorial introduces a Research Topic focused on coma and disorders of consciousness (DoC), stemming from the Curing Coma Campaign. It highlights the campaign's goal of unifying coma as a treatab...
KEY FINDING: Standardized neurobehavioral rating scales can improve diagnostic accuracy in DoC, leading to more effective treatment planning.