Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 81-90 of 7,812 results
J Chem Neuroanat, 2012 • May 1, 2012
This study describes the spatial distribution of PlexinA4 in the rat spinal cord, as well as its co-expression with markers of motor neurons throughout the adult spinal cord. Evidence of PlexinA4 expr...
KEY FINDING: PlexinA4 immunolabeling was found in neurons in both dorsal and ventral horns of the spinal cord, with more PlexinA4 positive neurons in the ventral horn.
Exp Neurol, 2012 • June 1, 2012
This study investigates the roles of neuronal (NRP) and glial (GRP) precursors in overcoming the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs) after spinal cord injury (SCI). The res...
KEY FINDING: Neurons derived from NRPs are intrinsically less sensitive to CSPGs, enabling them to extend axons across CSPG-rich areas.
Cell Tissue Res., 2012 • July 1, 2012
Axonal regeneration in the adult CNS is inhibited by multiple mechanisms, including inhibitory molecules, glial and inflammatory reactions, and insufficient stimulation of axonal growth. Neurotrophic ...
KEY FINDING: Combining neurotrophic factors with cell transplantation can promote robust axonal growth into cellular transplants.
PNAS, 2012 • May 8, 2012
The study addresses the failure of axon regeneration in the CNS due to a developmental decline in the intrinsic ability of neurons to extend axons, focusing on the transcription factor KLF7. To overco...
KEY FINDING: VP16-KLF7 effectively promotes neurite outgrowth and displays enhanced expression compared to wild-type KLF7 in dissociated neurons.
Spinal Cord Series and Cases, 2023 • July 12, 2023
This article is a correction to the legend of Fig. 3 in a previously published case report. The correction clarifies the effect of autogenic biofeedback training on gastric electrical activity in a pa...
KEY FINDING: The participant with SCI's gastric electrical activity decreased and its variability decreased, becoming progressively closer to the normal range of 3 cycles per minute after autogenic biofeedback training.
Mol Cell Neurosci, 2012 • June 1, 2012
This study investigates the role of PlexinA2 in limiting axonal growth and recovery after CNS injury. It finds that PlexinA2, a receptor for oligodendrocyte-derived Sema6A, restricts axon growth in th...
KEY FINDING: Outgrowth from adult PlexinA2-/- neurons is not inhibited by Sema6A in vitro.
Cell Mol Neurobiol, 2012 • May 10, 2012
This study investigates the mechanism by which neural stem cell (NSC) transplantation improves functional outcomes after spinal cord injury (SCI) in rats. The study found that NSC transplantation impr...
KEY FINDING: Transplantation of NSCs significantly improved hindlimb locomotor functions in adult rats subjected to transection of the spinal cord.
PLoS ONE, 2012 • May 22, 2012
This study investigated the gene expression differences between wild-type and EphA4 knockout mice following spinal cord injury to understand the mechanisms underlying functional recovery. Microarray a...
KEY FINDING: EphA4 knockout mice show altered expression of genes related to inflammation following spinal cord injury, specifically an attenuated expression of inflammatory genes.
J Control Release, 2012 • August 10, 2012
This study introduces drug-eluting microfibrous patches as a platform for the local delivery of rolipram to treat spinal cord injuries in rats. The patches were designed to control the release of roli...
KEY FINDING: Low-dose rolipram patches led to significant improvements in functional outcomes, with higher Martinez forelimb open-field scores compared to all other groups.
Drug Discov Today, 2012 • September 1, 2012
This review discusses advances in non-viral gene delivery for spinal cord injury (SCI) treatment. Non-viral vectors offer a safer alternative to viral vectors, with higher DNA-carrying capacity and th...
KEY FINDING: Non-viral gene vectors can transfect endogenous cells in the injured spinal cord, leading to the production of therapeutic molecules and long-lasting biological effects.