Spinal Cord Injury Research

KEY FINDING: CBG pre-treatment mitigates apoptosis signaling and manages oxidative stress in injured cells.

KEY FINDING: 70% of participants were rehospitalized within the first five years after initial discharge, with the highest rates occurring in the first year (54%).

KEY FINDING: ADS increased cortically-evoked spikes in spinal cord neurons at specific combinations of spike-ISMS delays and numbers of pulses.

KEY FINDING: NHOs developing after SCI in injured muscles in mice are not derived from muscle SCs. We also reveal that NHOs only develop in areas of the injured muscle where SCs fail to regenerate myofibers.

KEY FINDING: All four QOL domains (Physical Health, Psychological, Social Relationships, and Environment) showed a statistically significant decrease in individuals with SCI during the COVID-19 pandemic.

KEY FINDING: Citrate synthase (CS) activity, a measure of mitochondrial mass, was negatively associated with visceral adipose tissue (VAT) and C-reactive protein (CRP), an inflammatory marker.

KEY FINDING: VO2max increased significantly in the early chronic group (<3 years since injury) after six months of FES row training, while it did not change in the late chronic group (>3 years since injury).

KEY FINDING: SCs enhance axon regeneration through secretion of neurotrophic factors (NGF, BDNF, CNTF, and NT-3) and expression of adhesion molecules (L1 and NCAM) and ECM components (laminin, fibronectin, and collagen).

KEY FINDING: The WPAL improves walking independence in people with a wide range of spinal cord injuries, including cervical spinal cord injuries.

KEY FINDING: The primary outcome measure is upper extremity motor impairment assessed using the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP) scale.