Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 31-40 of 2,298 results
CNS Drugs, 2011 • July 1, 2011
Repair of the central nervous system (CNS) constitutes the integral part in treating neurologic diseases and plays a crucial role in restoring CNS architecture and function. In this review, we discuss...
KEY FINDING: The major challenges of CNS repair include neurodegeneration and pathological obstacles impeding neural cell growth after CNS injury.
Journal of Visualized Experiments, 2011 • June 22, 2011
This protocol establishes an in vitro system to study lens regeneration mechanisms in newts, allowing for gain-of-function and loss-of-function experiments. The aggregates, either dorsal or ventral, f...
KEY FINDING: Dorsal iris reaggregates maintain lens-forming capacity, while ventral aggregates do not, mimicking the in vivo process.
STEM CELLS, 2011 • January 1, 2011
Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. The mechanisms by which HSCs and MSCs might promote ...
KEY FINDING: MSCs can modify the environment around the spinal cord injury to support the regeneration of axons, the long fibers of nerve cells. They do this by reducing inflammation and creating an environment that supports axon growth.
PLoS ONE, 2011 • June 30, 2011
The study aimed to enhance the survival and neuronal differentiation of transplanted NSPCs in spinal cord injured rats using dbcAMP. Pre-treating NSPCs with dbcAMP before transplantation significantly...
KEY FINDING: NSPC survival was highest in the group pre-treated with dbcAMP, showing approximately 80% survival at both 2 and 6 weeks after transplantation.
PLoS ONE, 2011 • July 1, 2011
This study investigates the role of 6-sulphated chondroitins in axonal regeneration using C6ST-1 knockout mice. The researchers examined axon regeneration in both the central and peripheral nervous sy...
KEY FINDING: C6ST-1 knockout mice showed diminished regeneration of nigrostriatal TH-positive axons compared to wild-type animals after CNS injury.
Nature, 2011 • July 14, 2011
This study investigates methods to restore respiratory activity after cervical spinal cord injury (SCI) by targeting perineuronal net (PNN) associated chondroitin sulfate proteoglycans (CSPGs) around ...
KEY FINDING: ChABC treatment alone promotes plasticity of spared tracts and restores limited activity to the paralyzed diaphragm.
BMC Developmental Biology, 2011 • August 16, 2011
This study introduces the leopard gecko, Eublepharis macularius, as a laboratory model for studying regeneration, highlighting its tail autotomy and regeneration capabilities. The research establishes...
KEY FINDING: Tail regeneration in leopard geckos involves a conserved sequence of events, allowing for the creation of a staging table.
Neurotherapeutics, 2011 • September 15, 2011
This review highlights the progress in developing astrocyte transplantation therapies for CNS repair, emphasizing the importance of astrocytes as supporting cells for neuronal replacement. The authors...
KEY FINDING: Pre-differentiating GRP cells into GDAsBMP before transplantation promotes axonal regeneration, neuronal survival, tissue realignment, and functional recovery in transected rat spinal cords.
PLoS ONE, 2011 • September 13, 2011
This study provides evidence that soluble inhibitors of EphA4 function can be used therapeutically to promote recovery from spinal cord injury in mice. Two EphA4 blockers, ephrin-A5-Fc and EphA4-Fc, w...
KEY FINDING: Administration of either ephrin-A5-Fc or EphA4-Fc for 2 weeks following spinal cord injury resulted in substantial axonal regeneration, with many axons entering and crossing the lesion site.
Exp Neurol, 2012 • February 1, 2012
This study was designed as a direct replication of a previous experiment that reported inosine promotes the growth of corticospinal tract (CST) axons across the midline of the spinal cord after injury...
KEY FINDING: Intracortical delivery of inosine did not trigger extensive growth of CST axons across the astroglial boundary at the midline of the dorsal column following unilateral pyramidotomy.