Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,211-2,220 of 2,298 results
J Comp Neurol, 2009 • March 1, 2009
This study characterized SPRR1A expression in the DRG and spinal cord of adult mice following injury to the peripheral and central projections of DRG neurons, finding that SPRR1A induction correlates ...
KEY FINDING: SPRR1A expression is minimal following injury to the centrally projecting branches of DRG neurons.
JOURNAL OF NEUROTRAUMA, 2009 • January 1, 2009
This study demonstrates that ibuprofen promotes recovery from spinal cord contusion through a complex mechanism including axonal sprouting, neuroprotection, and raphespinal regeneration. Ibuprofen tre...
KEY FINDING: Ibuprofen reduces ligand-induced Rho signaling and myelin-induced inhibition of neurite outgrowth in vitro.
BioMed Central, 2009 • January 6, 2009
This study demonstrates that the sea cucumber Holothuria glaberrima can fully regenerate its radial nerve cord (RNC) after transection, restoring its morphology and cellular composition within a month...
KEY FINDING: Holothuria glaberrima can regenerate its radial nerve cord within a month following transection.
BMC Biology, 2009 • January 13, 2009
Microarray analysis and 454 cDNA sequencing were used to identify nerve-dependent and independent gene expression changes during limb regeneration in the Mexican axolotl. The results show that limb re...
KEY FINDING: Considerable similarity was observed between NR and DL transcriptional programs at 5 and 14 days post amputation (dpa).
Glia, 2009 • August 15, 2009
This study investigates the effects of GDNF on axonal regeneration and myelination following SCI, focusing on whether GDNF acts directly on neurons or indirectly through SCs. The results indicate that...
KEY FINDING: GDNF enhances both the number and caliber of regenerated axons in vivo and increases neurite outgrowth of dorsal root ganglion neurons (DRGN) in vitro, suggesting that GDNF has a direct effect on neurons.
Exp Neurol, 2009 • May 1, 2009
This study investigates the expression of myelin inhibitors Nogo-A and MAG during oligodendrogliogenesis and their effects on neurite outgrowth. The findings reveal that OPCs express Nogo-A but not MA...
KEY FINDING: OPCs express the intracellular domain of Nogo-A but not MAG, while mature oligodendrocytes express both.
Exp Neurol, 2009 • June 1, 2009
This study investigates the expression of RGM and its receptor neogenin in the sea lamprey spinal cord after injury. It aims to understand their roles in axon regeneration, which occurs in lampreys bu...
KEY FINDING: RGM mRNA is expressed in the spinal cord of sea lampreys, primarily in neurons of the lateral gray matter and dorsal cells.
Regen Med, 2009 • March 1, 2009
The study demonstrates that a Cx43 carboxyl-terminal peptide (ACT1) can accelerate wound closure and improve the quality of skin healing in both mouse and pig models. ACT1 treatment leads to reduced i...
KEY FINDING: Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin.
PNAS, 2009 • April 28, 2009
The study investigates methods to induce regeneration of corticospinal axons, which are crucial for motor function but typically do not regenerate after injury. The researchers hypothesized that enhan...
KEY FINDING: Overexpression of trkB in layer V motor cortex in vivo induces axonal regeneration after subcortical axotomy.
Curr Biol, 2009 • June 9, 2009
The mammalian CNS typically does not regenerate well after injury. However, prior research showed that a 'conditioning lesion' to peripheral axons of dorsal root ganglion (DRG) neurons can promote reg...
KEY FINDING: DRG neurons can be conditioned peripherally even after a central lesion has occurred, upregulating regeneration-associated genes (RAGs) similarly to conditioning before CNS injury.