Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 11-20 of 2,298 results
The Journal of Neuroscience, 2011 • March 16, 2011
This study demonstrates that olfactory ensheathing glia (OEG) transplantation promotes axon regeneration across a complete spinal cord transection in adult rats. The research highlights that this rege...
KEY FINDING: OEG transplantation promotes axon regeneration across a complete spinal cord transection in adult rats, as evidenced by electrophysiological and anatomical assessments.
Neuroscience, 2011 • June 2, 2011
The study investigates the expression of neurotrophins (NTs) and their Trk receptors in larval lampreys after spinal cord injury (SCI). Results showed that NT expression is initially downregulated nea...
KEY FINDING: NT expression was downregulated in neurons close to the transection at 2 weeks post-transection, but returned to control levels by 4 weeks.
Mt Sinai J Med, 2011 • March 1, 2011
The review examines potential avenues for oligodendrocyte protection and endogenous myelin repair in multiple sclerosis (MS) and its animal models, emphasizing the importance of these approaches for i...
KEY FINDING: Neurotrophins, such as NGF and NT-3, can influence myelination, with NGF affecting neurons and NT-3 having potent glial effects.
The Journal of Neuroscience, 2011 • March 23, 2011
This study demonstrates that neural progenitor cells (NPCs) can be used to create a neuronal relay across the injured spinal cord, forming synaptic connections with host neurons and restoring function...
KEY FINDING: Neural progenitor cells can be grafted into the injured spinal cord to form a neuronal relay by extending axons across the injury site.
Eur J Neurosci, 2011 • May 1, 2011
This study investigates the role of miR-133b in spinal cord regeneration in adult zebrafish. The research demonstrates that miR-133b expression increases in specific brainstem neurons following spinal...
KEY FINDING: miR-133b expression is upregulated in regenerating neurons of the brainstem after spinal cord transection in adult zebrafish.
PNAS, 2011 • April 12, 2011
This study investigates the role of STAT3, a transcription factor, in axon regeneration in the peripheral and central nervous systems using in vivo imaging and genetic manipulations in mice. The findi...
KEY FINDING: Deletion of STAT3 in dorsal root ganglia (DRG) neurons impairs regeneration of peripheral DRG branches after a nerve cut.
PLoS ONE, 2011 • March 28, 2011
This study identifies gecko CD59 as a molecule implicated in proximodistal (PD) identity during tail regeneration in Gekko japonicus. The researchers found that CD59 expression is dynamically regulate...
KEY FINDING: CD59 transcripts display a graded expression in the adult gecko spinal cord with the highest level in the anterior segment, with a stable expression along the normal tail.
The Journal of Neuroscience, 2011 • April 6, 2011
This study systematically investigates the impact of prolonged motoneuron axotomy, distal nerve stump denervation, and muscle denervation on functional recovery after peripheral nerve repair using a r...
KEY FINDING: Chronic denervation of the distal nerve stump plays a crucial role in reducing nerve regeneration after peripheral nerve injury.
Nature Communications, 2021 • August 13, 2021
This study reveals how physical activity regulates the creation of new nerve cells in adult zebrafish spinal cords through the interaction of two neurotransmitters: acetylcholine (ACh) and GABA. The st...
KEY FINDING: Physical activity induces animal growth and proliferation in the spinal cord.
PNAS, 2011 • May 10, 2011
The study demonstrates that Smad1-dependent BMP signaling is developmentally regulated and governs axonal growth potential in DRG neurons. Reactivation of Smad1 in adult DRG neurons, achieved through ...
KEY FINDING: Smad1-dependent BMP signaling is developmentally regulated and governs axonal growth in dorsal root ganglion (DRG) neurons.