Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 101-110 of 2,298 results
Glia, 2013 • February 1, 2013
This study investigates the effect of conditional Sox9 ablation on gene expression, glial scarring, and functional recovery after SCI. Sox9 conditional knock-out improved hind limb motor function in m...
KEY FINDING: Conditional Sox9 knock-out mice expressed reduced levels of CSPG biosynthetic enzymes, CSPG core proteins, collagens, and Gfap in the injured spinal cord.
PLoS ONE, 2012 • September 25, 2012
This study investigates the potential of neural stem cells (NSCs) engineered to secrete a trimerized form of the L1 cell adhesion molecule to promote spinal cord regeneration in mice. The researchers ...
KEY FINDING: Stem cells expressing trimeric and full-length L1 are more efficient in promoting locomotor recovery compared to stem cells overexpressing only full-length L1 or the parental stem cells.
Exp Neurobiol, 2012 • September 1, 2012
Injured primary sensory axons fail to regenerate into the spinal cord, leading to chronic pain and permanent sensory loss. Recent imaging studies that directly monitored axons arriving at the DREZ in ...
KEY FINDING: Injured sensory axons fail to regenerate into the spinal cord due to the DREZ.
Cell Adhesion & Migration, 2012 • November 1, 2012
Two recent studies show that activating integrin signaling in dorsal root ganglion (DRG) neurons renders them able to overcome inhibitory signals, and could possibly lead to new strategies to improve ...
KEY FINDING: Addition of CSPGs to dorsal root ganglion (DRG) cultures resulted in a reduction of activated integrins and growth inhibition. By adding manganese to the cultures, both FAK phosphorylation and growth response was restored, indicating that integrin activation is sufficient to override the inhibitory effects of CSPGs.
Stem Cells International, 2012 • September 5, 2012
Human adult teeth and periodontium retain populations of NCSCs that show characteristics of pluripotency. Dental and periodontal stem cells are currently being experimentally tested in various tooth a...
KEY FINDING: Dental EMSCs constitutively express neural-progenitor protein markers, even in basal culture conditions. This suggests that EMSCs may retain the intrinsic ability to redifferentiate to nerve cells.
The Journal of Neuroscience, 2012 • November 7, 2012
Lu et al. (2012) provide an important contribution to the field of neuroscience in demonstrating axonal regeneration following partial and complete cord transection. Perhaps surprisingly, this regener...
KEY FINDING: A combinatorial treatment strategy promoted axonal regeneration in both hemisection and full transection models.
Brain Behav Evol, 2012 • January 1, 2012
The present study examined proliferation and survival of cells following complete spinal cord transection rather than tail amputation in the weakly electric fish Apteronotus leptorhynchus. Spinal tran...
KEY FINDING: Spinal cord transection significantly increased the density of BrdU+ cells along the entire length of the spinal cord at 1 day post transection (dpt), and most newly generated cells survived up to 14 dpt.
STEM CELLS TRANSLATIONAL MEDICINE, 2012 • October 10, 2012
This review examines the potential of SDF-1 and its receptors to enhance stem cell function in spinal cord repair, highlighting its role in recruiting stem cells, promoting cell survival and maturatio...
KEY FINDING: SDF-1 is crucial for recruiting transplanted stem cells and endogenous progenitor cells to promote functional recovery after spinal cord injury.
Int. J. Mol. Sci., 2012 • October 10, 2012
Successful nerve regeneration after nerve trauma is not only important for the restoration of motor and sensory functions, but also to reduce the potential for abnormal sensory impulse generation that...
KEY FINDING: Transplanted OECs integrate into peripheral nerve transected by crush injury, form peripheral-like myelin on regenerated peripheral nerve fibers and that the OECs are able to signal the regenerated axons to reconstruct nodes of Ranvier (Figure 1A,B) with proper sodium channel (Nav1.6) organization
Journal of Biological Chemistry, 2013 • January 18, 2013
This study demonstrates that JNK1 is a key component in Netrin signaling, which is crucial for axon guidance during nervous system development. The researchers found that Netrin-1 activates JNK1 in ne...
KEY FINDING: Netrin-1 increases JNK1 activity, but not JNK2 or JNK3, in the presence of DCC or DSCAM, and expression of both further enhances Netrin-1-induced JNK1 activity in vitro.