Browse the latest research summaries in the field of neuroplasticity for spinal cord injury patients and caregivers.
Showing 41-50 of 153 results
Brain Pathology, 2023 • January 1, 2023
This study examined Nogo-A expression in human spinal cord injury (SCI) at the lesion core and perilesional rim, focusing on its role in plasticity and axonal damage. The research compared spinal cord...
KEY FINDING: Nogo-A expression is dominated by TPPP/p25+ oligodendrocytes after SCI.
PNAS, 2022 • June 27, 2022
The study investigated the effect of movement-dependent electrical stimulation on strengthening cortical connections in behaving monkeys. Movement-gated stimulation, paired with further repetition of ...
KEY FINDING: Movement-gated stimulation combined with postconditioning behavior produces further strengthening of cortical connections.
Frontiers in Molecular Neuroscience, 2022 • June 27, 2022
This study explores the composition and cellular sources of CSPGs, specifically lecticans, in the glial scar formed after spinal cord injury (SCI) in lampreys. The research identifies four lecticans (...
KEY FINDING: Lampreys express four main types of lecticans (A, B, C, and D), which are found in both glial cells and neurons.
Indian Journal of Nuclear Medicine, 2022 • July 8, 2022
This study used FDG PET scans to compare brain glucose metabolism in SCI patients and healthy controls, revealing areas of both increased and decreased metabolic activity. The results indicate that hy...
KEY FINDING: Increased metabolism was observed in the supplementary motor areas, comprehension centers, parts of the parietal and temporal lobes, putamen, and cerebellum in SCI patients.
Int. J. Mol. Sci., 2022 • August 21, 2022
The study evaluated the effects of paired stimulation on the SCI rat brain and spinal cord using different combinations of rTMS, iTBS, and tsDCS. iTBS/tsDCS stimulation for 3 min significantly changed...
KEY FINDING: Three-minute stimulation with iTBS/tsDCS significantly increased MEP after week 2 and week 4 treatments.
The Journal of Spinal Cord Medicine, 2020 • May 1, 2020
The study aimed to determine if combined G-CSF and treadmill exercise treatment provides a greater functional recovery advantage after spinal cord injury (SCI) in rats compared to either treatment alo...
KEY FINDING: Rats in the G-CSF/exercise group showed the most effective functional recovery based on the BBB scale and inclined plane test results.
PLoS ONE, 2019 • September 26, 2019
This study investigated the impact of repeated cathodal transspinal stimulation on soleus H-reflex excitability and spinal inhibition in individuals with and without chronic SCI. The research involved...
KEY FINDING: Repeated transspinal stimulation reduced soleus H-reflex excitability in both motor incomplete and complete SCI, but not in healthy control subjects.
JOURNAL OF NEUROTRAUMA, 2020 • March 15, 2020
This study investigates the role of KCC2, a neuronal chloride extruder, and BDNF in mediating the beneficial effects of activity-based therapies on spasticity following spinal cord injury (SCI). The r...
KEY FINDING: The activity-dependent increase in KCC2 functionally contributes to H-reflex recovery after spinal cord injury.
Journal of Clinical Medicine, 2019 • December 4, 2019
This review discusses the neuroplastic changes that occur in the brain following spinal cord injury (SCI), focusing on how the brain adapts to the loss of sensory and motor signals from the affected b...
KEY FINDING: Brain reorganization after SCI involves changes in the somatosensory and motor cortices, including the expansion of facial representation into areas formerly representing the affected limbs.
JOURNAL OF NEUROTRAUMA, 2020 • March 15, 2020
This study assessed the contributions of long and short propriospinal neurons (PSNs) and rubrospinal tract (RST) neurons to axonal projections caudal to a thoracic hemisection in cats. Results showed ...
KEY FINDING: The number of long propriospinal neurons (PSNs) with axons extending below the lesion was significantly and permanently decreased after injury.