Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 11-20 of 1,773 results
Neuroscience, 2011 • July 14, 2011
This study investigates the role of microRNAs (miRNAs) in spinal cord injury (SCI) by comparing miRNA expression in contused and sham rat spinal cords at 4 and 14 days post-injury. The researchers ide...
KEY FINDING: Several miRNAs, including miR124, miR129, and miR1, were significantly down-regulated following spinal cord contusion, while miR21 was significantly induced.
Gene Ther., 2012 • January 1, 2012
This study systematically compared seven AAV serotypes and an integration-deficient lentiviral vector for their ability to transduce corticospinal neurons (CSNs) following intracortical injection in r...
KEY FINDING: AAV1 was the most effective serotype for transducing cortical and CSNs, with GFP expression detectable in fibers projecting through the dorsal corticospinal tract (dCST) of the cervical spinal cord.
Cell Tissue Res., 2011 • June 1, 2011
This study investigates the cellular mechanisms of spinal cord regeneration in fresh-water turtles, focusing on cell proliferation and cytoarchitectural changes following injury. The research demonstr...
KEY FINDING: Spinal cord transection induces a significant increase in cell proliferation around the lesion epicenter in turtles.
J Neurosci Methods, 2011 • August 15, 2011
This study demonstrates the efficacy of a lentiviral vector (Chase/LV) encoding chondroitinase AC (Chase) in vitro and in vivo to degrade CSPGs. Chase/LV-infected cells showed sustained expression of ...
KEY FINDING: Neural precursor cells infected with Chase/LV expressed the GFP reporter, and the expression increased over time in culture, indicating successful transduction and expression of the transgene.
Cell Mol Neurobiol, 2011 • May 21, 2011
This study investigates the expression and role of ephrinA ligands, particularly ephrinA1, after spinal cord injury (SCI) in adult rats. The researchers found that ephrinA1 mRNA levels were significan...
KEY FINDING: EphrinA1 was the only ligand whose mRNA levels were significantly altered after SCI.
J Comp Neurol, 2011 • December 15, 2011
This study investigates the assembly properties of lamprey neurofilaments (NFs) and their expression following spinal cord transection. The findings challenge the previous assumption that lampreys pos...
KEY FINDING: Lamprey NFs require multiple subunits for assembly, including L-NFL (a lamprey NFL homolog) and NFM-like subunits (NF95, NF132, and NF180).
Nat Neurosci., 2011 • August 1, 2011
The study investigates the role of Axin2, a Wnt signaling target, in newborn brain injury and remyelination. It finds Axin2 expression in immature oligodendrocyte progenitor cells (OLP) within white m...
KEY FINDING: AXIN2 mRNA marks OLP in human neonatal white matter injury
Journal of Visualized Experiments, 2011 • June 22, 2011
This protocol establishes an in vitro system to study lens regeneration mechanisms in newts, allowing for gain-of-function and loss-of-function experiments. The aggregates, either dorsal or ventral, f...
KEY FINDING: Dorsal iris reaggregates maintain lens-forming capacity, while ventral aggregates do not, mimicking the in vivo process.
PLoS ONE, 2011 • July 1, 2011
This study investigates the role of 6-sulphated chondroitins in axonal regeneration using C6ST-1 knockout mice. The researchers examined axon regeneration in both the central and peripheral nervous sy...
KEY FINDING: C6ST-1 knockout mice showed diminished regeneration of nigrostriatal TH-positive axons compared to wild-type animals after CNS injury.
JoVE, 2011 • July 18, 2011
This protocol combines the DRG injury model with chromatin immunoprecipitation to investigate the transcriptional and epigenetic environment after injury to either the PNS or CNS. The ChIP protocol is...
KEY FINDING: The protocol demonstrates fragmented DNA to a length of approximately 200-1000 bp following sonication.