Transplantation of Neural Stem Cells Loaded in an IGF-1 Bioactive Supramolecular Nanofiber Hydrogel for the Effective Treatment of Spinal Cord Injury

Spinal cord injuries lead to cell death and loss of motor function. Stem cell transplants are a possible treatment, but they don't always work well because the injury environment is not conducive to cell survival and growth. This study introduces a new hydrogel that contains insulin-like growth factor-1 (IGF-1). The hydrogel helps neural stem cells (NSCs) survive, grow, and turn into neurons and oligodendrocytes, which are important for nerve function. The hydrogel also encourages the growth of nerve fibers and myelin regeneration at the injury site. Additionally, it concentrates beneficial substances (EVs) that promote axon regeneration and remyelination, even in an inflammatory environment. This approach shows promise as a treatment for spinal cord injuries.

• 1
  IGF-1 gel promotes NSC survival, proliferation, and differentiation into neurons and oligodendrocytes.
• 2
  NSCs carried in IGF-1 gels enhanced neurite outgrowth and myelin sheath regeneration at lesion sites.
• 3
  IGF-1 gels enriched extracellular vesicles (EVs) derived from NSCs via miRNAs related to axonal regeneration and remyelination.