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  4. Tetraplegic spinal cord injury as a presentation of multiple myeloma: A case report

Tetraplegic spinal cord injury as a presentation of multiple myeloma: A case report

Clin Case Rep, 2023 · DOI: 10.1002/ccr3.7667 · Published: June 26, 2023

Spinal Cord InjuryCardiovascular ScienceOncology

Simple Explanation

Multiple myeloma is a cancer of plasma cells that often affects bones. This case report describes an unusual presentation where the cancer compressed the spinal cord, leading to tetraplegia. The patient, a 79-year-old man, initially experienced back pain and leg weakness, which rapidly progressed to paralysis. Imaging revealed a lesion on the T1 vertebra causing spinal cord compression. The case highlights the importance of considering spinal cord compression in patients with multiple myeloma, as early diagnosis and intervention may prevent severe neurological complications.

Study Duration
Not specified
Participants
A 79-year-old Caucasian man
Evidence Level
Case Report

Key Findings

  • 1
    The patient presented with acute-onset paraplegia secondary to spinal cord compression from a T1 vertebral lesion caused by multiple myeloma.
  • 2
    Despite surgical decompression and chemotherapy, the patient experienced limited neurological recovery and developed complications such as DVT and steroid-induced hypercalcemia.
  • 3
    The case underscores the challenges of managing spinal cord injury complicated by underlying malignancy and the impact on functional outcomes and long-term care planning.

Research Summary

This case report describes a 79-year-old man who presented with tetraplegia secondary to spinal cord compression caused by multiple myeloma affecting the T1 vertebra. The patient underwent surgical decompression and was treated with chemotherapy, but experienced limited neurological recovery and significant complications. The case highlights the importance of considering malignant spinal cord compression in the differential diagnosis of atraumatic pain with neurological deficits, and the complex management challenges associated with spinal injury and cancer rehabilitation.

Practical Implications

Early Diagnosis

Clinicians should consider multiple myeloma and spinal cord compression in patients presenting with atraumatic back pain and neurological symptoms.

Prompt Imaging

Urgent imaging is warranted in cases of suspected spinal cord compression to facilitate timely intervention.

Multidisciplinary Approach

Management of these patients requires a multidisciplinary approach involving neurosurgery, oncology, rehabilitation, and aged care services.

Study Limitations

  • 1
    Single case report limits generalizability.
  • 2
    Limited information on long-term outcomes after discharge to aged care.
  • 3
    The patient's age and comorbidities may have influenced treatment decisions and outcomes.

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