Targeted tissue engineering: hydrogels with linear capillary channels for axonal regeneration after spinal cord injury

Spinal cord injury often leads to permanent loss of function due to the failure of axons to regenerate in the central nervous system. Researchers are exploring strategies like cell transplantation, bioactive compounds, and gene transfer to encourage axon regrowth and improve outcomes. One promising approach involves using hydrogels with linear channels to guide axon growth and create a supportive environment for regeneration.

• 1
  Scaffolds with linear channels can physically guide axon growth across the lesion and reduce contact with the inhibitory microenvironment.
• 2
  Combining biomaterials with cells improves morphological and functional outcomes by providing a matrix for cell adhesion and enhancing cell survival.
• 3
  Channel diameter in hydrogels influences axon growth density and orientation, with smaller diameters promoting better linear orientation.