Neural Regen Res, 2012 · DOI: 10.3969/j.issn.1673-5374.2012.16.008 · Published: June 1, 2012
Spinal cord injury is a serious trauma to the central nervous system leading to high incidence of disability and cost, posing a significant burden on patients and their families due to the loss of spinal neurons and lack of neurogenesis. Tissue-engineered cell transplantation is a new approach for treating spinal cord injury, which may repair or regenerate injured axons and recover partial spinal functions. The mechanisms of cell transplantation, which promote neural regeneration in damaged spinal function include: (1) Providing necessary conditions for neuronal and axonal regeneration; (2) To substitute or generate new neurons to form new synapses; and (3) To guide axons for alignment in order in tissue-engineered scaffolds to form new synapses.
The study identifies global research trends in stem cell transplantation for spinal cord injury, providing valuable insights for researchers in the field.
Highlights the prominence of BMMSCs and ESCs in spinal cord injury research, suggesting areas of focus and potential for further investigation.
Reveals the significant contributions of American and Japanese researchers and institutions, indicating centers of excellence and potential collaboration opportunities.