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  4. Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury

Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury

Neuroscience Bulletin, 2019 · DOI: https://doi.org/10.1007/s12264-018-0320-9 · Published: December 17, 2018

Spinal Cord InjuryNeurologyPain Management

Simple Explanation

This review explores the potential of spinal cord stimulation (SCS) for treating chronic pain following spinal cord injury (SCI). Alleviating pain is crucial for improving the quality of life for SCI patients, alongside restoring other functions. SCS, which involves using electrical pulses to modulate nerve activity, has been used for managing various chronic pain conditions. However, its effectiveness and mechanisms in SCI pain are not fully understood due to limited research and methodological issues in past studies. The review outlines different SCS approaches for SCI pain, including conventional, burst, and high-frequency stimulation. It also discusses the challenges of treating SCI pain and future research directions for improving SCS therapy.

Study Duration
Not specified
Participants
Review article, clinical studies mentioned with varying participant numbers
Evidence Level
Review

Key Findings

  • 1
    Conventional SCS may be more effective for reducing pain in patients with incomplete SCI, particularly those with lesions at low thoracic to upper lumbar levels.
  • 2
    Newer SCS paradigms, such as burst SCS, might be effective for below-level pain, even in cases of complete paraplegia.
  • 3
    High-frequency, paresthesia-free SCS can induce pain relief in patients who do not respond well to conventional SCS.

Research Summary

This review assesses the use of spinal cord stimulation (SCS) for the treatment of chronic pain after spinal cord injury (SCI). While restoring motor and other functions is important, alleviating pain is crucial for improving the quality of life for SCI patients. Conventional SCS, burst SCS, and high-frequency SCS are discussed as potential SCS paradigms for SCI pain. The review also emphasizes the need for further research to identify optimal SCS techniques and patient selection criteria for SCI pain management. The authors conclude that further research is needed to improve the effectiveness of SCS for SCI pain, including preclinical studies to understand the mechanisms of action and clinical trials to optimize treatment protocols.

Practical Implications

Personalized Treatment

SCS treatment should be tailored to each SCI patient based on their residual neuronal substrates and functional status.

Combination Therapies

Exploring the potential of combining SCS with other neuromodulation modalities, such as oscillating spinal field stimulation, may improve outcomes.

Further Research

Additional research is needed to understand the underlying mechanisms of SCS and identify the optimal SCS parameters and patient selection criteria.

Study Limitations

  • 1
    Methodological weaknesses in available clinical studies.
  • 2
    Lack of mechanistic studies of SCS for SCI pain.
  • 3
    Limited long-term outcome data for SCS in SCI pain management.

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