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  4. Spinal cord injury can be relieved by the polysaccharides of Tricholoma matsutake by promoting axon regeneration and reducing neuroinflammation

Spinal cord injury can be relieved by the polysaccharides of Tricholoma matsutake by promoting axon regeneration and reducing neuroinflammation

NeuroReport, 2020 · DOI: 10.1097/WNR.0000000000001514 · Published: January 1, 2020

Spinal Cord InjuryPharmacologyNeurology

Simple Explanation

Spinal cord injuries (SCIs) are becoming more common in China and often lead to limb dysfunction. Inflammation after SCI contributes to the problem. This study looks at how Tricholoma matsutake polysaccharides (TMP) might help with recovery after SCI. The study found that TMP promotes nerve growth and reduces inflammation in cells. In mice with SCI, TMP improved nerve regeneration and reduced inflammation.

Study Duration
Not specified
Participants
36 male C57 mice
Evidence Level
Not specified

Key Findings

  • 1
    TMP promoted neurite growth and inhibited the production of TNFα, IL-6, and NF-kappa B in cells treated with hydrogen peroxide.
  • 2
    In mice with SCI, TMP treatment led to a significant increase in BMS scores and nerve regeneration compared to the SCI group.
  • 3
    TMP treatment in mice with SCI significantly decreased NF-kappa B signaling, TNFα, and IL-6 production.

Research Summary

This study investigates the protective effects of Tricholoma matsutake polysaccharides (TMP) on spinal cord injuries (SCIs) both in vitro and in vivo. The results showed that TMP promotes neuronal proliferation and neurite growth while inhibiting neuroinflammation in vitro. Additionally, TMP improves spinal cord injuries in mouse models by promoting nerve cell regeneration and inhibiting inflammation. The conclusion of the study is that TMP has a protective effect against SCIs and may be a potential strategy for future clinical applications.

Practical Implications

Potential Therapeutic Strategy

TMP could be explored as a therapeutic agent for SCI due to its neuroprotective and anti-inflammatory effects.

Clinical Application

The findings provide scientific grounds for the application of TMP in clinical treatment of SCI.

Further Research

Further studies are needed to elucidate the related mechanism of TMP's action on SCI.

Study Limitations

  • 1
    Focused only on acute infections.
  • 2
    Related mechanism begs for more diverging studies.
  • 3
    Not specified

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