Safety and Efficacy of Riluzole in Traumatic Spinal Cord Injury: A Systematic Review With Meta-Analyses

Traumatic spinal cord injury (SCI) often leads to long-term disability. This study investigates riluzole's effectiveness versus placebo or standard care. The study found that riluzole may improve motor scores and ASIA Impairment Scale (AIS) scores, though not significantly. Riluzole was associated with fewer adverse events and lower mortality, but these results were not statistically significant.

• 1
  Riluzole showed a trend toward increased ASIA motor scores at 3 and 6 months post-injury, but not statistically significant.
• 2
  There was a trend toward improvement in ASIA Impairment Scale (AIS) at 3 and 6 months with riluzole, but not statistically significant.
• 3
  Riluzole was associated with fewer adverse events and lower mortality compared to the control groups, but again, not statistically significant.