Resolution of chronic migraine headaches with intrathecal ziconotide: a case report

Migraine headaches are a common problem, especially for women, and can make it hard to work or enjoy family life. Regular treatments don't always work well for chronic migraine. Ziconotide is a drug that can help with severe pain, and this case report looks at whether it can help with migraines. A woman with multiple sclerosis, spasticity, leg pain, and severe migraines was treated with ziconotide via an intrathecal pump. She had previously tried many migraine treatments without much success. After starting ziconotide, the patient's leg pain improved and her migraines completely stopped for 8 months. This is the first reported case of ziconotide helping with migraines, suggesting it could be a new treatment option.

• 1
  The patient experienced complete resolution of migraine headaches following the initiation of low-dose intrathecal ziconotide (1 µg/day).
• 2
  Prior to ziconotide, the patient had 22 migraine headache days per month, which were reduced to 4 with Botox injections, but resolved completely with ziconotide.
• 3
  The patient was able to discontinue the use of triptans and significantly reduce the use of NSAIDs after starting ziconotide treatment.