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  4. Protocol for the Chinese Real-­World Evidence for Acute Spinal Cord Injury (ChiRES) study: a prospective, observational, multicentre cohort study of acute spinal cord injury

Protocol for the Chinese Real-­World Evidence for Acute Spinal Cord Injury (ChiRES) study: a prospective, observational, multicentre cohort study of acute spinal cord injury

BMJ Open, 2024 · DOI: 10.1136/bmjopen-2023-080358 · Published: January 1, 2024

Spinal Cord InjuryResearch Methodology & Design

Simple Explanation

This study aims to create a large collection of information and samples from patients with recent spinal cord injuries in China. This will help to improve clinical research and treatment standards. The project will gather detailed data, including patient history, emergency care, and various examinations, to develop tools that can predict complications and outcomes for these patients. Researchers will also analyze imaging and blood samples to find markers that can help predict how well patients will recover, and they aim to determine the best timing for surgical treatment.

Study Duration
At least 1 year
Participants
2097 patients with acute SCI
Evidence Level
Observational, multicentre cohort study

Key Findings

  • 1
    The study aims to establish a multicentre database of clinical information and biospecimen samples of patients with acute SCI and to complete at least 1 year of follow-­up.
  • 2
    The research seeks to assess the current state of acute SCI management and identify gaps by comparing it with existing guidelines.
  • 3
    A key objective is to develop biochemical blood markers and imaging markers that can predict the prognosis of acute SCI early on.

Research Summary

The ChiRES study is designed as a prospective, multicentre cohort study to gather comprehensive data on Chinese patients with acute SCI. The study will collect detailed clinical data, blood samples, and imaging results to identify biomarkers and develop prediction models for complications and prognoses. The ultimate goal is to improve the systematisation and standardisation of clinical research and treatment of acute SCI, thus reducing the heavy burden on patients and society.

Practical Implications

Improved Clinical Practice

The study aims to identify deficiencies in current SCI management and provide evidence to inform clinical practice.

Personalized Treatment

Developing a clinical decision-aid system for acute SCI to achieve personalized management of complications and early intervention.

Standardized Surgical Protocols

Clarifying the optimal timing of surgical treatment and developing a standardized protocol for surgical treatment of acute SCI.

Study Limitations

  • 1
    This research exclusively takes place in China, which may limit the generalisability of the findings.
  • 2
    The study relies on observational data, which may be subject to biases and confounding factors.
  • 3
    General limitations associated with cohort studies.

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