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  4. Neither Postabsorptive Resting Nor Postprandial Fat Oxidation Are Related to Peak Fat Oxidation in Men With Chronic Paraplegia

Neither Postabsorptive Resting Nor Postprandial Fat Oxidation Are Related to Peak Fat Oxidation in Men With Chronic Paraplegia

Frontiers in Nutrition, 2021 · DOI: 10.3389/fnut.2021.703652 · Published: July 26, 2021

Spinal Cord InjuryEndocrinologyNutrition & Dietetics

Simple Explanation

This study looked at how the body uses fat for energy in men with spinal cord injuries, both at rest and during exercise. It measured fat oxidation at rest, after eating, and during an arm exercise test. The study found that how well the body burns fat at rest or after eating isn't related to how well it burns fat during exercise. However, the ability to burn fat at rest was related to the ability to burn fat after eating. These results suggest that assessing fat oxidation both at rest and during exercise might give a more complete picture of metabolic health in people with spinal cord injuries.

Study Duration
Not specified
Participants
10 adult men with chronic thoracic spinal cord injury (SCI)
Evidence Level
Not specified

Key Findings

  • 1
    Postabsorptive fat oxidation at rest was significantly and positively correlated with postprandial peak fat oxidation.
  • 2
    Peak fat oxidation was not significantly associated with postabsorptive fat oxidation at rest, postprandial peak fat oxidation, or incremental area under the curve postprandial fat oxidation.
  • 3
    There was a strong positive correlation between VO2peak and peak fat oxidation.

Research Summary

The study investigated the relationship between fat oxidation (FO) at rest and after eating (postprandial) with peak fat oxidation (PFO) during exercise in men with spinal cord injuries (SCI). The primary finding was that neither postabsorptive FO at rest nor postprandial peak FO were related to PFO. Instead, significant correlations were found between FO at rest and postprandial, and between VO2peak and PFO. These results suggest that assessing both postabsorptive FO at rest and PFO may provide a more complete understanding of metabolic flexibility and long-term metabolic health in individuals with SCI.

Practical Implications

Metabolic Assessment

Both postabsorptive fat oxidation at rest and peak fat oxidation should be assessed to gain a complete picture of metabolic flexibility in those with SCI.

Intervention Targets

Effective interventions can be targeted to those most in need based on a better understanding of their metabolic flexibility.

Clinical Practice

PFO may not be a reliable marker of metabolic flexibility in those with SCI, unlike in non-injured individuals, highlighting the need for different assessment approaches.

Study Limitations

  • 1
    The study did not include any female participants.
  • 2
    It would have been optimal to feed our participants a meal with an energy content that was standardized relative to fat-free mass.
  • 3
    Our finding that PFO occurred in the first stage of the GXT may mean that in some participants we missed the workload that elicited PFO

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