Spinal Cord Research Help
AboutCategoriesLatest ResearchContact
Subscribe
Spinal Cord Research Help

Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

Quick Links

  • Home
  • About
  • Categories
  • Latest Research
  • Disclaimer

Contact

  • Contact Us
© 2025 Spinal Cord Research Help

All rights reserved.

  1. Home
  2. Research
  3. Spinal Cord Injury
  4. Mechanical properties of nerve roots and rami radiculares isolated from fresh pig spinal cords

Mechanical properties of nerve roots and rami radiculares isolated from fresh pig spinal cords

Neural Regeneration Research, 2015 · DOI: 10.4103/1673-5374.170319 · Published: November 1, 2015

Spinal Cord InjuryBiomechanics

Simple Explanation

This study investigates the strength characteristics of nerve roots and rami radiculares, which are components of the cauda equina. The cauda equina is a bundle of nerve roots in the lower spinal canal that can be affected by conditions like cauda equina syndrome. The researchers performed tensile tests on nerve roots and rami radiculares extracted from fresh pig spinal cords. These tests measured the stress-strain relationship and strength under different conditions. The study found that nerve root tensile strength was not dependent on the rate of strain, while the tensile strength of rami radiculares tended to decrease as the strain rate increased. This suggests different responses to force and speed of injury between these structures.

Study Duration
Not specified
Participants
Two pigs, hybrid (Landrace and Duroc), aged 13 months, weighing 120–130 kg, both genders
Evidence Level
Not specified

Key Findings

  • 1
    The tensile strength of the nerve root was not rate dependent, remaining relatively constant around 0.7 MPa across different strain rates.
  • 2
    The tensile strength of the ramus radiculares tended to decrease as the load strain rate increased, suggesting a higher susceptibility to injury with increasing speed of force application.
  • 3
    Nerve roots exhibited a superelastic pattern in stress-strain relationships, while ramus radiculares showed a stepwise decrease in stress after reaching a peak, with the decrease becoming more rapid as the strain rate increased.

Research Summary

This study aimed to determine the strength characteristics of spinal nerve roots and rami radiculares to better understand the pathogenesis of cauda equina syndrome. Monoaxial tensile tests were performed on nerve roots and rami radiculares isolated from pig spinal cords to evaluate their stress-strain relationship and strength characteristics under different load strain rates. The results showed that the tensile strength of nerve roots was not rate-dependent, whereas the tensile strength of rami radiculares tended to decrease as the strain rate increased, providing insights into the clinical symptoms of cauda equina syndrome and related conditions.

Practical Implications

Understanding Injury Mechanisms

The findings contribute to understanding how nerve roots and rami radiculares respond to mechanical stress, aiding in explaining injury mechanisms in conditions like cauda equina syndrome.

Clinical Relevance

The study highlights differences in the mechanical properties of nerve roots and rami radiculares, which can help explain the diverse symptoms observed in medullary cone lesions and cauda equina syndrome.

Finite Element Analysis

The data obtained can be used for finite element method analyses to correlate mechanical properties of pig tissues with clinical symptoms, potentially improving diagnostic and therapeutic strategies.

Study Limitations

  • 1
    [object Object]
  • 2
    [object Object]
  • 3
    [object Object]

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury