Large animal models of human cauda equina injury and repair: evaluation of a novel goat model

This study introduces a novel goat model for studying cauda equina injury and repair, addressing limitations of previous rat models due to size differences from humans. The research focuses on establishing this goat model and using electrophysiological, histological, and MRI methods to evaluate outcomes after injury and surgical repair. The study aims to provide detailed information on nerve regeneration processes following surgical repair, potentially leading to improved treatments for cauda equina injuries.

• 1
  The study successfully established a goat experimental model that mimics human cauda equina injury, allowing for surgical repair and outcome monitoring.
• 2
  Electrophysiological examinations revealed cross-innervation of tail muscles by cauda equina nerves, suggesting functional redundancy and potential for nerve transfer.
• 3
  MRI-DTI was found to be effective for diagnosing and prognosing cauda equina injury in goats, providing detailed visualizations of nerve structures.