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  4. Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study

Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study

Global Spine Journal, 2024 · DOI: 10.1177/21925682241297587 · Published: January 1, 2024

Spinal Cord InjuryEndocrinologyNeurology

Simple Explanation

This study investigates how diabetes mellitus affects neurological recovery in older patients with cervical spinal cord injury (CSCI) without bone injury. The research involved a retrospective analysis of 389 patients aged 65 years and older, comparing neurological outcomes between diabetic and non-diabetic individuals after a cervical spinal cord injury without bone injury. The study also examined the impact of moderate-severe diabetes, defined by hemoglobin A1c levels or insulin treatment, on the neurological recovery of these patients.

Study Duration
2010-2020
Participants
389 patients aged ≥65 years with CSCI without bone injury
Evidence Level
Not specified

Key Findings

  • 1
    Diabetic patients with CSCI without bone injury achieved similar neurological function improvements compared to non-diabetic patients.
  • 2
    Moderate-severe diabetes did not significantly affect neurological recovery in patients with CSCI without bone injury.
  • 3
    Age, dementia, and baseline total ASIA motor scores (AMS) were identified as negative predictors of neurological recovery at 6 months post-injury.

Research Summary

This study aimed to investigate the impact of diabetes on post-injury complications and neurological recovery, and the relationship between moderate-severe diabetes and neurological recovery in patients with CSCI without bone injury. Propensity score matching revealed no significant differences in the degree of improvement in AMS at 6 months post-injury between the nondiabetic and diabetic groups. Multiple linear regression analysis indicated that moderate-severe diabetes did not affect the degree of improvement in AMS.

Practical Implications

Clinical Decision-Making

Findings support that diabetes should not be a deterrent for medical treatment of patients with CSCI without bone injury.

Personalized Rehabilitation

Clinicians should focus on personalized rehabilitation approaches, especially for elderly patients, focusing on daily living activities and motivation.

Multidisciplinary Care

A multidisciplinary approach is crucial, focusing on preventing prolonged immobility and complications in patients with dementia.

Study Limitations

  • 1
    Retrospective study design leading to missing values.
  • 2
    Heterogeneous cohort without a control group.
  • 3
    Short follow-up period of 6 months post-injury.

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