Spinal Cord Research Help
AboutCategoriesLatest ResearchContact
Subscribe
Spinal Cord Research Help

Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

Quick Links

  • Home
  • About
  • Categories
  • Latest Research
  • Disclaimer

Contact

  • Contact Us
© 2025 Spinal Cord Research Help

All rights reserved.

  1. Home
  2. Research
  3. Spinal Cord Injury
  4. Factors Associated With Ventilator Weaning Success and Failure in People With Spinal Cord Injury in an Acute Inpatient Rehabilitation Setting: A Retrospective Study

Factors Associated With Ventilator Weaning Success and Failure in People With Spinal Cord Injury in an Acute Inpatient Rehabilitation Setting: A Retrospective Study

Top Spinal Cord Inj Rehabil, 2022 · DOI: 10.46292/sci21-00062 · Published: July 1, 2022

Spinal Cord InjuryCritical CareRehabilitation

Simple Explanation

This study looked at factors that help people with spinal cord injuries (SCI) get off ventilators in rehab. It found that those who got off the ventilator sooner after their injury, had better breathing capacity when admitted, and had injuries lower down the spine were more likely to successfully wean. The research also showed that a breathing capacity measurement of 5.8 mL/kg PBW (predicted body weight) or higher was a good sign that someone could be weaned off the ventilator. The study highlights that vital capacity is a better predictor of weaning success than the level of the spinal cord injury.

Study Duration
2015 to 2019
Participants
91 adults with acute traumatic SCI dependent on mechanical ventilation
Evidence Level
Not specified

Key Findings

  • 1
    People who successfully weaned had fewer days from time of SCI to AIR admission.
  • 2
    People who successfully weaned had higher vital capacity at admission to AIR.
  • 3
    Vital capacity was a better predictor of weaning from mechanical ventilation compared to the neurological level of injury, with a cutoff of 5.8 mL/kg PBW predictive of weaning success.

Research Summary

This retrospective study evaluated baseline characteristics, described pulmonary outcomes, and identified weaning predictors for people with acute traumatic spinal cord injury (SCI) who are dependent on mechanical ventilation at admission to acute inpatient rehabilitation (AIR). People who successfully weaned (85%) had fewer days from time of SCI to AIR admission (22 vs. 30, p = .04), higher vital capacity at admission to AIR (12 vs. 3 mL/kg predicted body weight [PBW]; p < .001), and lower (caudal) neurological injury level (p < .001) compared to those who failed weaning. Vital capacity was a better predictor of weaning from mechanical ventilation compared to the neurological level of injury, with a cutoff of 5.8 mL/kg PBW predictive of weaning success.

Practical Implications

Improved Weaning Prediction

Vital capacity (VC) at admission to AIR can be used to predict weaning success, with a cutoff value of 5.8 mL/kg PBW.

Targeted Interventions

Early recognition of patients at high risk of weaning failure allows early application of treatments such as phrenic nerve pacing, diaphragmatic pacing, and abdominal functional electrical stimulation.

Optimized Ventilator Management

Evaluation of vital capacity might prevent premature weaning or unnecessary prolongation of mechanical ventilation in people with SCI.

Study Limitations

  • 1
    Selection bias and information bias inherent in retrospective studies
  • 2
    Small sample size
  • 3
    Lack of generalizability due to the single institution setting

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury