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  4. Early versus late surgical intervention for cervical spinal cord injury A protocol for systematic review and meta-analysis

Early versus late surgical intervention for cervical spinal cord injury A protocol for systematic review and meta-analysis

Medicine, 2023 · DOI: http://dx.doi.org/10.1097/MD.0000000000033322 · Published: March 1, 2023

Spinal Cord InjurySurgeryResearch Methodology & Design

Simple Explanation

This study reviews the best timing for surgery after a cervical spinal cord injury (SCI). Early surgery, within 24 hours, is compared to later surgery to see which leads to better outcomes. The review looks at various databases for randomized controlled trials on this topic. The study will assess the quality of the included studies and statistically analyze the data. The goal is to provide evidence-based recommendations for the optimal timing of surgical decompression in patients with acute SCI.

Study Duration
Not specified
Participants
Patients with acute cervical SCI
Evidence Level
Systematic review and meta-analysis protocol

Key Findings

  • 1
    The primary outcome will be the change in the American Spinal Injury Association score from baseline to follow-up.
  • 2
    Secondary outcomes include neurological improvement rate, mortality, length of stay, and postoperative complications.
  • 3
    The risk of bias will be appraised using the Cochrane Collaboration tool for randomized controlled trials.

Research Summary

This systematic review and meta-analysis protocol aims to compare the efficacy of early versus late surgical intervention for acute cervical spinal cord injury (SCI). The study will search multiple databases for randomized controlled trials and assess the risk of bias in included studies using the Cochrane Collaboration tool. The results will be published in a peer-reviewed journal and will provide evidence regarding the optimal timing for spinal cord decompression in patients with acute SCI.

Practical Implications

Clinical Practice

The review aims to inform clinical practice regarding the optimal timing of surgical intervention for acute cervical SCI.

Guidelines Development

The findings could contribute to the development or refinement of clinical guidelines for the management of acute SCI.

Future Research

The study highlights the need for high-quality evidence to address the gap between guideline recommendations and clinical practice.

Study Limitations

  • 1
    Limited to Chinese and English language publications
  • 2
    Reliance on published data and potential for publication bias
  • 3
    Heterogeneity among studies may complicate data synthesis

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