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  4. Critical illness myopathy in a cervical spine-injured patient

Critical illness myopathy in a cervical spine-injured patient

Spinal Cord Series and Cases, 2016 · DOI: 10.1038/scsandc.2016.17 · Published: July 14, 2016

Spinal Cord InjuryCritical CareNeurology

Simple Explanation

Critical illness myopathy (CIM) is a condition causing muscle weakness in ICU patients, often due to factors like sepsis or prolonged ventilation. It's characterized by muscle fiber atrophy and loss of a protein called myosin. This case report describes a patient with a cervical spine injury who developed CIM while in the ICU. This is notable because there are no prior reports of CIM following spinal cord injury. The patient experienced muscle weakness in his limbs, neck, and face after his spine injury. Diagnostic tests, including a muscle biopsy, confirmed the presence of CIM.

Study Duration
Not specified
Participants
A 23-year-old male
Evidence Level
Case Report

Key Findings

  • 1
    A 23-year-old male with a cervical spine injury developed critical illness myopathy (CIM) while in the ICU, a previously unreported occurrence.
  • 2
    The patient's CIM diagnosis was confirmed via muscle biopsy, which revealed myosin filament loss, a key characteristic of the condition.
  • 3
    Electrophysiological studies, including nerve conduction studies and electromyography, played a crucial role in differentiating CIM from other potential causes of weakness, such as critical illness polyneuropathy (CIP).

Research Summary

This case report describes a unique instance of critical illness myopathy (CIM) in a 23-year-old male who sustained a cervical spine injury and was admitted to the ICU. The patient developed significant muscle weakness, and the diagnosis of CIM was confirmed through muscle biopsy, revealing myosin filament loss. Early identification and evaluation of new-onset weakness in ICU patients, particularly those with spinal cord injuries, are crucial to distinguish between neurological causes and complications of critical illness, enabling timely intervention and promoting recovery.

Practical Implications

Early Diagnosis

Prompt evaluation of weakness in ICU patients, especially those with spinal cord injuries, is critical for distinguishing between neurological causes and complications of critical illness.

Diagnostic Testing

Utilize electrophysiological studies and muscle biopsy to accurately diagnose CIM and differentiate it from other conditions like CIP.

Preventative Strategies

Implement preventative measures such as aggressive treatment of sepsis and strict glycemic control to reduce the risk of developing CIM and CIP.

Study Limitations

  • 1
    Single case report limits generalizability.
  • 2
    Lack of specific details on long-term outcomes.
  • 3
    Absence of a control group for comparison.

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