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  4. Cortical activation during visual illusory walking in persons with spinal cord injury: A pilot study

Cortical activation during visual illusory walking in persons with spinal cord injury: A pilot study

Arch Phys Med Rehabil, 2015 · DOI: 10.1016/j.apmr.2014.10.020 · Published: April 1, 2015

Spinal Cord InjuryNeuroimagingPain Management

Simple Explanation

This study investigates brain activity during a visual illusion of walking in people with spinal cord injury (SCI) compared to those without SCI. The goal was to understand how visual illusions might help treat SCI-related neuropathic pain. Participants were shown videos of someone walking or using a wheelchair while their brain activity was measured using fMRI. They were asked to imagine themselves performing the actions in the videos. The study found different patterns of brain activity in the SCI group compared to the able-bodied group, suggesting that visual illusions may target specific areas of the brain that are affected by SCI.

Study Duration
Not specified
Participants
3 persons with paraplegia and 5 able bodied participants
Evidence Level
Level Not specified, Pilot experimental fMRI trial

Key Findings

  • 1
    Persons with SCI showed significant activation in the somatosensory cortex during visually illusory walking.
  • 2
    Able-bodied participants showed significant activation in the bilateral frontal and premotor cortex during visually illusory walking.
  • 3
    Able-bodied participants found the visual simulation more immersive and were better able to imagine themselves as the actor compared to persons with SCI.

Research Summary

This pilot study used fMRI to examine cortical activation during a visual illusory walking paradigm in persons with SCI compared to able-bodied controls. The results showed significant activation in the somatosensory cortex among those with SCI, while able-bodied participants showed activation in the frontal and premotor areas. The study suggests that sensory input paradigms like visual illusory walking may target the somatosensory cortex, which is known to reorganize following SCI, and that further investigation is warranted.

Practical Implications

Targeted Therapy

Visual or virtual walking therapies for SCI-related neuropathic pain may work by specifically targeting the somatosensory cortex.

Differential Rehabilitation Strategies

Rehabilitation strategies may need to be tailored to address the different patterns of cortical activation observed in individuals with SCI compared to able-bodied individuals.

Further Research

Further investigation into the effectiveness of sensory input paradigms such as visual illusory walking is needed to determine its viability as a treatment for SCI-related neuropathic pain.

Study Limitations

  • 1
    The study is of course small
  • 2
    The effect on subjective pain levels were not measured here
  • 3
    More data will be needed to confirm differences in cortical activation

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