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  4. Changes in pain and quality of life in depressed individuals with spinal cord injury: does type of pain matter?

Changes in pain and quality of life in depressed individuals with spinal cord injury: does type of pain matter?

The Journal of Spinal Cord Medicine, 2016 · DOI: 10.1080/10790268.2016.1151145 · Published: January 1, 2016

Spinal Cord InjuryParticipationPain Management

Simple Explanation

This study looked at how different types of pain (neuropathic and nociceptive) affect the quality of life in people with spinal cord injuries who are also depressed. The study also looked at whether changes in pain affected mobility and independence. The study found that lower levels of nociceptive pain interference at the start of the study were linked to higher satisfaction with life and better mental health at the end of the 12-week study period. Lower levels of neuropathic pain interference were linked to changes in physical independence. The researchers concluded that the type of pain experienced after a spinal cord injury might affect how pain interference relates to quality of life. However, they found no strong links between pain and quality of life in this group of depressed individuals with spinal cord injuries.

Study Duration
12 weeks
Participants
108 persons with spinal cord injury and depression
Evidence Level
Not specified

Key Findings

  • 1
    Lower baseline nociceptive pain interference was associated with higher satisfaction with life and mental health-related QoL at 12 weeks.
  • 2
    Lower neuropathic pain interference was associated with change in physical independence, but unrelated to mobility.
  • 3
    Overall, there were no extensive relationships between pain and QoL in this sample of depressed persons with SCI.

Research Summary

The study examined the relationship between neuropathic and nociceptive pain, pain interference, and quality of life (QoL) in individuals with spinal cord injury (SCI) participating in an antidepressant trial for depression. The results indicated that lower baseline nociceptive pain interference was associated with higher satisfaction with life and mental health-related QoL at 12 weeks, while lower neuropathic pain interference was associated with changes in physical independence but not mobility. The study concluded that pain interference over time may be differentially related to QoL outcomes based on the type of pain following SCI, but overall, there were no extensive relationships between pain and QoL in this sample of depressed persons with SCI.

Practical Implications

Pain Management Strategies

Develop tailored pain management strategies that consider the type of pain (neuropathic vs. nociceptive) to improve QoL outcomes in depressed SCI patients.

Early Intervention

Address pain interference early in the course of SCI to potentially improve long-term satisfaction with life and physical independence.

Future Research

Further investigate the complex relationships between pain, QoL, mobility, and independence in larger, non-depressed SCI samples, considering specific sensory profiles and locations of pain.

Study Limitations

  • 1
    Participants had comorbid major depressive disorder, limiting generalizability.
  • 2
    The SCIPI is a subjective measure.
  • 3
    The study may have been underpowered to detect all relationships of interest.

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