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  4. Change in urodynamic pattern and incidence of urinary tract infection in patients with traumatic spinal cord injury practicing clean self-intermittent catheterization

Change in urodynamic pattern and incidence of urinary tract infection in patients with traumatic spinal cord injury practicing clean self-intermittent catheterization

The Journal of Spinal Cord Medicine, 2020 · DOI: 10.1080/10790268.2018.1512729 · Published: May 1, 2020

Spinal Cord InjuryUrologyImmunology

Simple Explanation

This study examines how bladder function changes over time in people with spinal cord injuries who use clean intermittent self-catheterization (CIC). CIC is a method where patients regularly empty their bladder using a catheter to prevent complications. The researchers looked at urodynamic parameters, which are measurements of bladder function, and the incidence of urinary tract infections (UTIs) in these patients. They wanted to see if regular CIC and medications could prevent bladder problems and UTIs. The study found that even with regular CIC, bladder capacity and compliance (how well the bladder stretches) decreased over time. UTIs were also common, especially in patients with overactive bladder muscles, and E. coli was the most common cause of these infections.

Study Duration
October 2011 to September 2013
Participants
31 persons with neurogenic bladder caused by traumatic SCI and practicing CIC
Evidence Level
Prospective, observational study

Key Findings

  • 1
    Cystometric capacity and compliance decreased significantly over time, despite regular CIC and antimuscarinic medication use.
  • 2
    UTIs were more common in individuals with SCI who had detrusor overactivity (DO).
  • 3
    Escherichia coli was the most common cause of UTIs in this population.

Research Summary

The study prospectively evaluated urodynamic changes in individuals with SCI practicing CIC to understand long-term complications despite CIC and compare the urodynamic bladder profile of overactive detrusor and detrusor areflexia groups. Cystometric capacity and compliance decreased significantly, and detrusor leak point pressure (DLPP) increased significantly over time despite regular CIC and management with antimuscarinics for detrusor overactivity. Urinary tract infections were more common in individuals with spinal cord injury and detrusor overactivity, with E. coli being the most frequent causative agent.

Practical Implications

Long-term Monitoring

Regular urodynamic evaluations are necessary for SCI patients practicing CIC to detect changes in bladder function and prevent complications.

Targeted UTI Prevention

SCI patients with detrusor overactivity require more intensive strategies to prevent UTIs.

Antibiotic Stewardship

Given the prevalence of E. coli in UTIs, empirical antibiotic choices should consider local resistance patterns of this organism.

Study Limitations

  • 1
    The sample size of 31 participants might limit the generalizability of the findings.
  • 2
    The study duration of 6 months to 1 year may not be sufficient to capture long-term urodynamic changes.
  • 3
    Electromyography was not included in the urodynamic studies, preventing comment on detrusor sphincter dyssynergia.

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