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  4. Case report – Gluteal hematoma in two spinal cord patients on enoxaparin for venous thromboembolism prophylaxis: evidence needed for a wiser choice

Case report – Gluteal hematoma in two spinal cord patients on enoxaparin for venous thromboembolism prophylaxis: evidence needed for a wiser choice

Spinal Cord Series and Cases, 2019 · DOI: 10.1038/s41394-019-0180-1 · Published: March 19, 2019

Spinal Cord InjuryCardiovascular SciencePharmacology

Simple Explanation

This report discusses the risk of blood clots in patients with spinal cord injuries, which is higher right after the injury. Doctors often prescribe blood thinners to prevent these clots, but it's not always clear how long the treatment should last, especially for patients with long-term injuries. The authors present two cases where patients with chronic spinal cord injuries developed large hematomas (collections of blood) in their buttocks while taking a common blood thinner called enoxaparin to prevent blood clots. The authors suggest that doctors might be overprescribing blood thinners to spinal cord injury patients, exposing them to unnecessary risks like bleeding. They emphasize the need for more research to better estimate the risk of blood clots in these patients and to determine the appropriate duration of preventive treatment.

Study Duration
Not specified
Participants
Two patients with chronic spinal cord injury
Evidence Level
Case Report

Key Findings

  • 1
    Two patients with chronic SCI developed gluteal hematomas while on prophylactic enoxaparin, requiring surgical intervention and delaying rehabilitation.
  • 2
    The cases suggest a potential overestimation of thromboembolic risk in chronic SCI patients, leading to unnecessary pharmacological prophylaxis.
  • 3
    Current clinical prediction rules for VTE risk may not be validated or applicable to the SCI population, potentially leading to inappropriate treatment decisions.

Research Summary

The case report highlights the occurrence of gluteal hematomas in two patients with chronic spinal cord injury who were receiving prophylactic enoxaparin for venous thromboembolism (VTE). The authors discuss the lack of clear guidelines for VTE prophylaxis duration in subacute and chronic SCI and suggest a potential overestimation of VTE risk in this population. The conclusion emphasizes the need for individualized risk assessment and further studies to better assess thromboembolic risk and guide prophylaxis decisions in spinal cord injury patients.

Practical Implications

Re-evaluate VTE Prophylaxis Guidelines

Current guidelines may need to be revised to address the specific needs of chronic SCI patients, considering the potential for overestimation of VTE risk.

Individualized Risk Assessment

Clinicians should conduct individualized risk assessments rather than relying solely on plegia when deciding on VTE prophylaxis for SCI patients.

Polypharmacy Reduction

Reducing prophylactic VTE treatment could be a starting point for reducing polypharmacy in SCI patients, given the potential for overestimation of VTE risk.

Study Limitations

  • 1
    Small sample size (two case reports)
  • 2
    Lack of validated risk assessment tools for VTE in SCI patients
  • 3
    Limited evidence on the actual thromboembolic risk in chronic SCI

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