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  4. Body composition and metabolic parameters in men with chronic traumatic paraplegia – A pilot study from India

Body composition and metabolic parameters in men with chronic traumatic paraplegia – A pilot study from India

The Journal of Spinal Cord Medicine, 2022 · DOI: 10.1080/10790268.2021.1888021 · Published: January 1, 2022

Spinal Cord InjuryEndocrinologyPhysiology

Simple Explanation

This study investigates the body composition and metabolic health of Indian men with paraplegia compared to able-bodied men. It focuses on understanding how spinal cord injury affects fat and muscle mass and how these changes relate to insulin resistance and cholesterol levels. The research utilizes DXA scans to measure body fat and lean mass, providing a more detailed assessment than BMI alone. This is crucial because BMI may not accurately reflect body fat distribution in individuals with spinal cord injuries. The findings reveal that men with paraplegia have lower muscle mass, higher fat mass, increased insulin resistance, and lower levels of good cholesterol (HDL-C). These factors collectively increase the risk of metabolic disorders and cardiovascular diseases.

Study Duration
3 Years
Participants
43 men with chronic traumatic paraplegia and 36 able-bodied men
Evidence Level
Cross sectional study

Key Findings

  • 1
    Men with paraplegia have significantly lower lean mass index (LMI) and appendicular lean mass index (ALMI) compared to able-bodied controls.
  • 2
    Subjects with paraplegia exhibit a higher percentage of total body fat (%FM) and altered regional adiposity, indicated by a lower trunk to leg fat ratio.
  • 3
    Individuals with paraplegia demonstrate increased insulin resistance, shown by higher HOMA-IR and lower QUICKI, along with lower HDL-C levels.

Research Summary

This study compared body composition and metabolic profiles of men with paraplegia to able-bodied men, finding that those with paraplegia had lower lean mass and higher fat mass despite similar BMIs. The study also found that men with paraplegia had increased insulin resistance and lower HDL-C levels compared to the control group, indicating a poorer metabolic profile. The researchers noted that body composition measures are better indicators of adiposity and sarcopenia in this population than BMI alone, though validated cutoffs are needed.

Practical Implications

Improved Assessment Methods

Body composition analysis should be prioritized over BMI for accurately assessing metabolic risk in individuals with paraplegia.

Targeted Interventions

Interventions aimed at increasing lean mass and reducing fat mass may improve metabolic health in men with paraplegia.

Personalized Healthcare

Healthcare providers should consider ethnicity when assessing body composition and metabolic risk in individuals with spinal cord injuries.

Study Limitations

  • 1
    Cross-sectional, observational design
  • 2
    Small sample size
  • 3
    Visceral adipose tissue was estimated from DXA measures

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