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  4. At-home genital nerve stimulation for individuals with SCI and neurogenic detrusor overactivity: A pilot feasibility study

At-home genital nerve stimulation for individuals with SCI and neurogenic detrusor overactivity: A pilot feasibility study

The Journal of Spinal Cord Medicine, 2019 · DOI: 10.1080/10790268.2017.1422881 · Published: May 1, 2019

Spinal Cord InjuryUrologyNeurology

Simple Explanation

This study explores using electrical stimulation of genital nerves (GNS) at home to help people with spinal cord injuries (SCI) who have bladder control problems. These problems, like involuntary bladder contractions (NDO), can affect health and quality of life. The study involved men with SCI and NDO using a portable GNS device at home for one month. Researchers tracked leakage events, bladder capacity, and satisfaction levels during stimulation, before, and after. The results showed that GNS reduced leakage events and participants were satisfied with how it helped them manage their bladder issues. The study suggests GNS could be a useful way to reduce bladder problems for those with SCI.

Study Duration
3 Months
Participants
Five men with SCI and NDO
Evidence Level
Pilot feasibility study

Key Findings

  • 1
    Genital nerve stimulation (GNS) reduced the number of leakage events from 1.0 ± 0.5 to 0.1 ± 0.4 leaks per day in the four subjects who reported incontinence data.
  • 2
    All study participants were satisfied that GNS met their bladder goals; wanted to continue using GNS; and would recommend it to others.
  • 3
    Bladder capacity increased acutely during each urodynamics in response to GNS by 156 ± 70 mL (ANOVA, P < 0.001, n = 14), regardless of treatment period.

Research Summary

This pilot study investigated the feasibility and effectiveness of at-home genital nerve stimulation (GNS) for individuals with spinal cord injury (SCI) and neurogenic detrusor overactivity (NDO). The study found that short-term at-home GNS reduced urinary incontinence and helped subjects meet their bladder management goals. All participants reported satisfaction with GNS and expressed a desire to continue using it, highlighting the potential of GNS as a viable approach to manage NDO following SCI.

Practical Implications

Clinical Trial Design

The data from this study informs the design of a larger, randomized, controlled clinical trial to further evaluate the long-term effectiveness and feasibility of GNS.

Personalized Bladder Management

GNS can be integrated into personalized bladder management strategies for individuals with SCI, offering an alternative or complementary approach to existing methods.

Implantable Systems

The positive user feedback and interest in implanted systems suggest a potential pathway for developing more convenient and effective GNS devices.

Study Limitations

  • 1
    Small sample size
  • 2
    Short chronic duration
  • 3
    Challenges of conducting such a study

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