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  4. A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder

A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder

Scientific Reports, 2018 · DOI: 10.1038/s41598-018-30232-z · Published: August 23, 2018

Spinal Cord InjuryUrologyNeurology

Simple Explanation

This study explores a non-invasive method to improve bladder function in people with spinal cord injuries (SCI) who struggle with voluntary urination. The method, transcutaneous magnetic spinal cord stimulation (TMSCS), involves using magnetic pulses to stimulate the spinal cord. Five individuals with SCI participated in the study. They received weekly TMSCS treatments, and their bladder function was monitored. The results showed improvements in bladder function during and after the TMSCS treatments. All participants were able to achieve volitional urination after the treatments. They experienced an increase in the amount of urine they could voluntarily produce and a decrease in the frequency of self-catheterization.

Study Duration
16 weeks treatment, 6 weeks follow-up
Participants
5 individuals with American Spinal Injury Association Impairment Scale A/B, chronic SCI and detrusor sphincter dyssynergia
Evidence Level
Not specified

Key Findings

  • 1
    Volitional urination was re-enabled in all five subjects with SCI following intermittent, non-invasive TMSCS.
  • 2
    The volume of urine produced voluntarily increased from 0 cc/day to 1120 cc/day (p = 0.03); self-catheterization frequency decreased from 6.6/day to 2.4/day (p = 0.04).
  • 3
    The capacity of the bladder increased from 244 ml to 404 ml (p = 0.02); and the average quality of life ranking increased significantly (p = 0.007).

Research Summary

This study investigated the potential of transcutaneous magnetic spinal cord stimulation (TMSCS) to improve bladder function in individuals with chronic spinal cord injury (SCI). Five participants with SCI received weekly TMSCS treatments, which led to improvements in bladder function, including volitional urination, increased urine volume, decreased self-catheterization frequency, and increased bladder capacity. The findings suggest that TMSCS may offer a non-invasive approach to neuromodulate spinal micturition circuitry and ameliorate bladder function in individuals with SCI, though the effects were not permanent.

Practical Implications

Potential Therapeutic Intervention

TMSCS may be a potential non-invasive therapeutic intervention for individuals with SCI and neurogenic bladder, offering an alternative or adjunct to existing treatments like self-catheterization.

Improved Quality of Life

The study demonstrates the potential for TMSCS to improve the quality of life for individuals with SCI by restoring volitional bladder function and reducing the need for frequent self-catheterization.

Further Research

The findings warrant further research to investigate the long-term efficacy and safety of TMSCS, optimize stimulation parameters, and elucidate the underlying mechanisms of action in restoring bladder function.

Study Limitations

  • 1
    Small sample size of five participants
  • 2
    Lack of a control group receiving a different intervention
  • 3
    Unclear long-term effects and durability of the treatment benefits

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