Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,291-5,300 of 5,401 results
J. Comp. Neurol., 2009 • August 20, 2009
This study investigates serotonergic innervation in the caudal spinal stump of rats after complete spinal transection, focusing on the impact of olfactory ensheathing glia (OEG) transplantation. The r...
KEY FINDING: Many 5-HT-labeled axons are present throughout the caudal stump of both media- and OEG-injected rats after complete spinal cord transection, suggesting the presence of 5-HT-labeled fibers is not a reliable indicator of regeneration.
Nat Neurosci, 2009 • July 1, 2009
This report demonstrates that chromatin remodeling enzymes HDAC1/2 regulate oligodendrocyte specification and differentiation, at least in part, by inhibiting β-catenin/TCF7L2 complex formation. The s...
KEY FINDING: HDAC1 and HDAC2 are essential for oligodendrocyte formation, and their deletion leads to a complete loss of oligodendrocytes.
J Neurochem, 2009 • July 1, 2009
The study demonstrates that inhibiting NF-κB in astrocytes promotes axonal sparing and sprouting after spinal cord contusion injury, contributing to improved functional recovery. Retrograde tracing sh...
KEY FINDING: Inhibition of NF-κB in astrocytes leads to reduced inflammation and improved functional recovery after spinal cord injury.
J Physiol, 2009 • June 15, 2009
The review explores central nervous system regeneration in leeches and neonatal opossums to understand the mechanisms that promote and prevent regeneration, contrasting these with the limited regenera...
KEY FINDING: Leech CNS regeneration involves microglial cells and nitric oxide, which facilitate axon regrowth and reconnection with appropriate synaptic targets.
TheScientificWorldJOURNAL, 2009 • June 12, 2009
The use of murine models of SCI has drastically increased in the last decade and, again, significant findings were made in 2008. Insights were provided into mechanisms underlying secondary degeneratio...
KEY FINDING: Two new mouse models of SCI using either graded forceps or Allen’s weight drop system were developed.
J Neuropathol Exp Neurol, 2009 • July 1, 2009
The study investigates the effect of co-transplanting embryonic neurons with neurotrophic factors on muscle reinnervation and function after sciatic nerve denervation in rats. The key finding is that ...
KEY FINDING: Adding GDNF, HGF, and IGF-1 to the cell transplant significantly increased motoneuron survival, myelinated axon counts, muscle reinnervation, and evoked EMG compared to cells alone.
J. Anat., 2009 • June 24, 2009
This study investigated the effect of cyclosporin A (CsA) on functional recovery and the cellular environment following spinal cord contusion injury in rats. CsA was administered to rats after a moder...
KEY FINDING: CsA treatment resulted in a short-term functional improvement at 3 weeks post-injury in the left hindlimbs of rats.
Exp Neurol, 2009 • November 1, 2009
The study developed a rat model of cervical contusion SCI using the Infinite Horizons device, creating mild and moderate injuries at different cervical levels. The injuries resulted in varying degrees...
KEY FINDING: Rats can survive significant bilateral cervical contusion injuries at or below C5.
JOURNAL OF NEUROTRAUMA, 2009 • December 1, 2009
This study investigated the temporospatial expression and cellular localization of OMgp following traumatic SCI in adult rats using a newly developed OMgp polyclonal antibody. The research found that ...
KEY FINDING: OMgp was almost exclusively expressed in the CNS, with slight expression in cardiac muscle and liver. It was not found in lung, kidney, or skeletal muscle.
Results Probl Cell Differ, 2009 • January 1, 2009
Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-...
KEY FINDING: The PNS environment is stimulatory and/or the CNS environment is inhibitory for axon growth.