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  4. Transcutaneous Electrical Spinal Stimulation Promotes Long-Term Recovery of Upper Extremity Function in Chronic Tetraplegia

Transcutaneous Electrical Spinal Stimulation Promotes Long-Term Recovery of Upper Extremity Function in Chronic Tetraplegia

IEEE Trans Neural Syst Rehabil Eng, 2018 · DOI: 10.1109/TNSRE.2018.2834339 · Published: June 1, 2018

Spinal Cord InjuryNeuroplasticityRehabilitation

Simple Explanation

This study explores using electrical stimulation on the spinal cord through the skin to help restore arm and hand function in people with tetraplegia. The goal was to see if this stimulation could encourage the nervous system to adapt and improve motor control over time. A 62-year-old man with a spinal cord injury participated in a program that included periods of electrical stimulation combined with physical therapy, physical therapy alone, and then another short period of stimulation and physical therapy. The results showed improvements in strength, sensation, and the ability to use his hands after the stimulation and therapy. These improvements lasted for more than three months even without ongoing treatment.

Study Duration
9 weeks intervention, 3 months follow-up
Participants
1 male with C3, incomplete, chronic spinal cord injury
Evidence Level
Not specified

Key Findings

  • 1
    Upper extremity muscle strength nearly doubled over the course of treatment and stabilized at 75% stronger than baseline for three months without further treatment.
  • 2
    Following only four weeks of stimulation + PT, overall neurological level of injury improved from C3 to C4 based on the ISNCSCI exam, and was sustained for the duration of the follow-up with no further treatment.
  • 3
    Lateral pinch force measured during stimulation increased 2- to 7-fold in the left and right hands, respectively.

Research Summary

This study investigated the effects of transcutaneous electrical spinal cord stimulation combined with physical therapy on upper extremity function in a 62-year-old male with chronic tetraplegia. The intervention consisted of alternating periods of stimulation + PT, PT only, and a brief return to stimulation + PT. Significant improvements were observed in muscle strength, GRASSP test scores, pinch strength, and neurological level of injury. Notably, these functional gains persisted for over three months without further treatment, suggesting the potential for long-term neuroplastic changes and recovery following spinal cord injury.

Practical Implications

Therapeutic Potential

Non-invasive electrical stimulation of spinal networks can promote neuroplasticity and long-term recovery following SCI.

Clinical Application

Transcutaneous spinal cord stimulation combined with activity-based exercise therapy can promote substantial functional recovery of upper extremities in chronic SCI.

Future Research

Further work is needed to explore and optimize the potential of transcutaneous spinal stimulation to restore function following various neurological injuries.

Study Limitations

  • 1
    Single case study limits generalizability.
  • 2
    The specific mechanisms of action are not fully understood.
  • 3
    Long-term effects beyond three months were not assessed.

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