Spinal Cord Research Help
AboutCategoriesLatest ResearchContact
Subscribe
Spinal Cord Research Help

Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

Quick Links

  • Home
  • About
  • Categories
  • Latest Research
  • Disclaimer

Contact

  • Contact Us
© 2025 Spinal Cord Research Help

All rights reserved.

  1. Home
  2. Research
  3. Spinal Cord Injury
  4. The presence or absence of midsagittal tissue bridges and walking: a retrospective cohort study in spinal cord injury

The presence or absence of midsagittal tissue bridges and walking: a retrospective cohort study in spinal cord injury

Spinal Cord, 2023 · DOI: 10.1038/s41393-023-00890-6 · Published: August 1, 2023

Spinal Cord InjuryNeuroimagingRehabilitation

Simple Explanation

This study investigates the relationship between tissue bridges in the spinal cord and walking ability in veterans with spinal cord injuries. Midsagittal tissue bridges are a measurement of preserved neural tissue. The researchers analyzed MRI scans of 22 veterans with cervical spinal cord injuries to determine the presence and width of these tissue bridges. They then compared these measurements to the participants' ability to walk. The study found that individuals with tissue bridges were more likely to be able to walk, and those without tissue bridges were unable to walk. The width of the tissue bridges also correlated with walking ability.

Study Duration
Not specified
Participants
22 United States veterans with cervical spinal cord injuries
Evidence Level
Level 3; Retrospective cohort study

Key Findings

  • 1
    71% of participants with midsagittal tissue bridges were able to walk overground.
  • 2
    All individuals with no apparent tissue bridges were unable to walk.
  • 3
    There was a significant correlation between walking and widths of ventral midsagittal tissue bridges (r = 0.69, p < 0.001) and dorsal midsagittal tissue bridges (r = 0.44, p = 0.039).

Research Summary

This study found an association between the presence/absence of midsagittal tissue bridges and walking ability in veterans with cervical spinal cord injury. The presence of ventral tissue bridges showed a stronger positive correlation with ambulation compared to dorsal bridges. The study suggests that evaluation of midsagittal tissue bridges could inform patient care, allocation of neuromodulatory resources, and stratification into research cohorts.

Practical Implications

Informing Rehabilitation Plans

Evaluating midsagittal tissue bridges may help guide rehabilitation approaches for individuals with SCI.

Stratifying Patients for Clinical Trials

Measuring tissue bridges in chronic SCI may be important for designing clinical trials and determining appropriate rehabilitation strategies.

Predictive Tool for Walking Ability

The evaluation of tissue bridges may become a standard part of an SCI interdisciplinary toolbox for walking prediction post-SCI.

Study Limitations

  • 1
    Observational study of a small cohort limits causation inference.
  • 2
    Walking ability was inferred from clinical documentation, lacking details on specific walking ability.
  • 3
    Walking assessment date was often following the MRI date.

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury