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  4. Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle

Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle

Biomedicines, 2022 · DOI: https://doi.org/10.3390/biomedicines10123221 · Published: December 12, 2022

PharmacologyGastroenterologyMusculoskeletal Medicine

Simple Explanation

This review focuses on the effects of BPC 157, a stable gastric pentadecapeptide, on various types of muscle including striated, smooth, and heart muscle. It explores BPC 157's potential in treating muscle injuries and disabilities arising from different causes. BPC 157 has shown positive healing effects on different injury types in numerous organ systems, especially the muscular system. It also aids in maintaining and recovering smooth muscle function and may promote the recovery of sphincter functions. The review also highlights BPC 157's role in counteracting tumor-induced muscle cachexia and its involvement in resolving activities of the brain–gut and gut–brain axes. Overall, it positions BPC 157 as a promising agent in muscle therapy with high curing potential and safety.

Study Duration
Not specified
Participants
Rats
Evidence Level
Review

Key Findings

  • 1
    BPC 157 therapy shows potential in healing severed myotendinous junctions, combining healing of transected and detached tendons, muscles, ligaments, and bones.
  • 2
    BPC 157 therapy may recover muscle disabilities caused by various conditions like succinylcholine, vascular occlusion, spinal cord compression, stroke, traumatic brain injury, electrolyte disturbances, neurotoxins, neuroleptics, alcohol, serotonin syndrome, NO-system blockade, and tumor-cachexia.
  • 3
    BPC 157 might aid in recovery for disabled heart functioning and disabled smooth muscle functioning, particularly in various sphincters.

Research Summary

The review explores the stable gastric pentadecapeptide BPC 157's effects on striated, smooth, and heart muscles, highlighting its healing potential for myotendinous junction injuries. BPC 157 therapy demonstrates the ability to organize simultaneous healing of different tissues and full recovery of the myotendinous junction, representing a particular muscle therapy against distinctive etiopathology muscle disabilities and weakness. BPC 157, stable in human gastric juice, is positioned as a prototype anti-ulcer cytoprotective peptide for muscle therapy with high curing potential, a very safe profile, and a wide effective range.

Practical Implications

Muscle Injury Treatment

BPC 157 could be developed as a therapeutic agent for muscle injuries, aiding in faster and more complete recovery.

Neuromuscular Disorder Management

BPC 157 might be useful in managing muscle disabilities arising from various neurological conditions and systemic disorders.

Cardiovascular and Smooth Muscle Function Improvement

BPC 157's potential to improve heart and smooth muscle function opens avenues for treating cardiovascular and gastrointestinal disorders.

Study Limitations

  • 1
    Limited clinical trials in humans
  • 2
    Mechanism of action not fully elucidated
  • 3
    Generalizability to different populations not established

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