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  4. Short- and long-­term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-­crank exercise capacity in individuals with a spinal cord injury (STIMEX-­SCI): study protocol

Short- and long-­term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-­crank exercise capacity in individuals with a spinal cord injury (STIMEX-­SCI): study protocol

BMJ Open, 2025 · DOI: 10.1136/bmjopen-2024-089756 · Published: January 1, 2025

Spinal Cord InjuryNeurologyRehabilitation

Simple Explanation

This study investigates how non-invasive spinal cord stimulation (TSCS) affects cardiovascular health and exercise ability in people with spinal cord injuries. The researchers will explore whether TSCS can improve autonomic function and exercise performance in the short term and enhance cardiorespiratory fitness and cardiometabolic health in the long term through an 8-week exercise program. The study involves acute and longitudinal components, utilizing arm-crank exercises and various measurements to assess the impact of TSCS.

Study Duration
8 weeks
Participants
16 individuals with SCI, 12 healthy controls
Evidence Level
Not specified

Key Findings

  • 1
    The study will examine whether TSCS improves volitional upper-body exercise capacity in the short- and long-term.
  • 2
    The application of TSCS during acute arm-crank exercise influences cardiovascular, cerebrovascular, metabolic and immune responses.
  • 3
    The study will determine to what extent autonomic responses at rest and during exercise are ‘normalised’ with the application of TSCS in the spinal cord injured cohort.

Research Summary

This study aims to determine the effects of transcutaneous spinal cord stimulation (TSCS) on cardiovascular control and exercise capacity in individuals with spinal cord injury (SCI). The study will investigate the short-term effects of TSCS on autonomic function and exercise performance during arm-crank exercise. The study will evaluate the long-term impact of TSCS combined with exercise on cardiorespiratory fitness, cardiometabolic health, and quality of life outcomes.

Practical Implications

Rehabilitation Strategies

TSCS may be an efficacious rehabilitative strategy to stimulate meaningful physiological adaptations to exercise in the acute setting following SCI.

Athletic Performance

Augmenting exercise capacity with TSCS may have important implications for supporting athletic and/or rehabilitation strategies following SCI.

Clinical Populations

The findings may stimulate further research into ameliorating the effects of ANS dysfunctions, altered motor function, or body composition in other clinical populations.

Study Limitations

  • 1
    The follow-up period will not include any physiological assessments.
  • 2
    The study does not permit a meaningful power calculation.
  • 3
    Potential attrition with the 8-week intervention and follow-up.

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