Research hotpots and frontier trends of neuroprotective effects of magnesium from 1999 to 2023: A bibliometric analysis

CNS Neurosci Ther, 2024 · DOI: 10.1111/cns.14597 · Published: January 1, 2024

Simple Explanation

Magnesium is a mineral that plays a crucial role in many bodily functions, including nerve and muscle function, and blood pressure regulation. It has been shown to have neuroprotective effects in various neurological disorders. Magnesium protects nerves through neuronal and vascular mechanisms, reducing excitotoxicity and improving energy balance after brain injury. It also regulates calcium levels in blood vessels, reducing vasospasm and improving blood flow. This study analyzes research on magnesium neuroprotection to understand current research directions and future trends. It uses bibliometric analysis to assess publications, countries, institutions, authors, citations, and keywords related to magnesium's neuroprotective effects.

Study Duration

24 Years

Participants

762 articles from 216 institutions in 64 countries

Evidence Level

Not specified

Key Findings

1
The United States had the largest number of publications, followed by China and Canada, indicating their prominent role in magnesium neuroprotection research.
2
Current research hotspots focus on magnesium therapy in neurovascular diseases such as cerebral ischemia, spinal cord injury, subarachnoid hemorrhage, and emerging treatment strategies.
3
The neuroprotective effects of magnesium in preterm infants have been extensively studied and adequately confirmed, while its therapeutic effects on cerebral ischemia and subarachnoid hemorrhage have been demonstrated mainly in animal models with less satisfactory clinical results.

Research Summary

This bibliometric analysis explores the neuroprotective effects of magnesium from 1999 to 2023, revealing research hotspots and trends using CiteSpace software to analyze publications, citations, and keywords. The study identifies the United States as the leading country in publications, with a focus on magnesium therapy for neurovascular diseases and preterm infants. Clinical trials, however, have shown limited success in cerebral ischemia and subarachnoid hemorrhage. The analysis suggests that combining magnesium with hypothermia shows potential as a future research direction. This review provides a comprehensive overview of the development and research focus in the field of magnesium neuroprotection.

Practical Implications

Perinatal Neural Protection

Magnesium therapy is effective for neural protection in preterm infants, reducing risks of cerebral palsy and motor dysfunction.

Ischemic Brain Disease Treatment

While animal studies show promise, clinical trials of magnesium for cerebral ischemia have not yielded significant improvements, necessitating new treatment strategies.

Combination Therapies

Combining magnesium with therapeutic hypothermia may enhance neuroprotective effects, offering a potential future treatment strategy for stroke and other neurological conditions.

Study Limitations

1
The study only included articles published in the WoSCC database from 1999 to 2023.
2
The language was restricted to English, and only original articles and reviews were included.
3
The data may not be comprehensive due to restrictions.

Your Feedback

Was this summary helpful?

Back to Neurology