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  4. Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital

Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital

Antibiotics, 2023 · DOI: 10.3390/antibiotics12111587 · Published: November 2, 2023

Spinal Cord InjuryImmunologyHealthcare

Simple Explanation

This study looks at the types of bacteria found in chronic wounds (pressure ulcers) of patients with spinal cord injuries. It aims to understand how common drug-resistant bacteria are in these infections. The research involved reviewing data from 203 patients admitted to a rehabilitation hospital between 2015 and 2021. The study identified the bacteria present in the wounds and their resistance to antibiotics. The findings help doctors make better choices about which antibiotics to use for these infections. This is important for improving treatment and reducing the spread of drug-resistant bacteria.

Study Duration
2015 to 2021
Participants
203 adult spinal cord injury patients with pressure ulcers
Evidence Level
Retrospective single-center study

Key Findings

  • 1
    Staphylococcus aureus was the most commonly isolated organism from ulcers, especially in sacral and gluteal regions.
  • 2
    A significant portion of the bacterial isolates exhibited resistance to multiple drugs; 7.88% were multidrug-resistant (MDR), and 2.46% were pan-drug-resistant (PDR).
  • 3
    Among the resistant isolates, 25.61% were methicillin-resistant S. aureus (MRSA), and 17.73% were extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae.

Research Summary

This retrospective study evaluated the prevalence of bacterial pathogens, particularly MDR and ESBL-producing bacteria, in pressure ulcers of spinal cord injury patients. The study found that S. aureus was the most common organism, with a notable presence of MDR and ESBL strains, highlighting the challenges in treating these infections. The findings emphasize the need for targeted antibiotic therapy and better antimicrobial stewardship to improve patient outcomes and reduce healthcare costs.

Practical Implications

Improved Antibiotic Selection

Understanding the prevalence and antibiotic susceptibility patterns of bacteria in pressure ulcers can lead to more informed antibiotic choices, reducing the use of broad-spectrum antibiotics.

Enhanced Infection Control

Identifying MDR and ESBL strains allows for better implementation of infection control measures, preventing the spread of these resistant organisms within healthcare facilities.

Development of Targeted Therapies

The study highlights the need for further research into novel therapeutic approaches for managing pressure ulcers, especially those infected with drug-resistant bacteria.

Study Limitations

  • 1
    Small sample size from a single center
  • 2
    The study is retrospective in nature
  • 3
    Lack of data on previous antibiotic exposure of patients

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