PREDICTION OF SERUM NEURITIN AND NEURON-SPECIFIC ENOLASE FOR PROGNOSIS IN PATIENTS WITH TRAUMATIC BRAIN INJURY COMBINED WITH SPINAL CORD INJURY

This study investigates the use of serum neuritin and neuron-specific enolase (NSE) levels to predict the prognosis of patients who have experienced both traumatic brain injury (TBI) and spinal cord injury (SCI). These biomarkers are believed to play a role in nerve cell recovery. The research involved 60 patients divided into three groups based on their prognosis: favorable, poor, or death. The levels of neuritin and NSE, along with other clinical indicators, were compared among the groups to assess their predictive value. The findings suggest that measuring serum neurofilament and NSE together can more accurately predict the prognosis of TBI and SCI patients than measuring either biomarker alone. This could help doctors make better decisions about treatment and care.

• 1
  Patients with poor outcomes (poor prognosis or death) had a significantly higher proportion of combined organ injuries and hypotension compared to those with favorable outcomes.
• 2
  Levels of platelets (PLT), D-dimer (D-D), antithrombin III (AT-III), S100b protein, NSE, and serum neurofilament were significantly higher in the groups with poorer prognoses.
• 3
  Combining the measurement of NSE and serum neurofilament significantly improved the accuracy of prognosis prediction compared to using either biomarker alone.