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  4. Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy

Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy

Frontiers in Neurology, 2024 · DOI: 10.3389/fneur.2024.1411182 · Published: June 24, 2024

Spinal Cord InjuryNeurologySpinal Disorders

Simple Explanation

This study investigates the usefulness of measuring spinal cord motion to diagnose degenerative cervical myelopathy (DCM). DCM is a condition where the spinal cord is compressed in the neck due to age-related changes. The study looks at two groups of DCM patients: those with visible damage on MRI scans (MRI+) and those without (MRI-). The goal is to see if spinal cord motion, measured using a special MRI technique, can help identify patients with nerve damage, especially in the MRI- group where diagnosis can be more challenging. The findings suggest that measuring spinal cord motion could be a valuable tool for early diagnosis and treatment of DCM, particularly in patients who don't show obvious signs of damage on standard MRI scans. This could lead to earlier surgical intervention and better outcomes.

Study Duration
October 2016 and December 2022
Participants
84 DCM patients classified as MRI+ or MRI−
Evidence Level
Cross-sectional study

Key Findings

  • 1
    Patients with and without visible spinal cord damage on MRI (MRI+ and MRI-) showed similar levels of increased spinal cord motion and compression.
  • 2
    In patients without visible spinal cord damage on MRI (MRI-), spinal cord motion measurements were able to identify those with clinical and neurophysiological signs of nerve damage.
  • 3
    Specific thresholds for spinal cord motion were identified: 1.67 mm for trunk/lower extremity pin prick score and 1.96 mm for contact heat evoked potentials, indicating potential benchmarks for identifying patients with nerve damage.

Research Summary

This cross-sectional study aimed to determine the significance of cardiac-related spinal cord motion and spinal stenosis as indicators of mechanical strain in degenerative cervical myelopathy (DCM) patients. The study found that spinal cord motion measurements could identify patients with nerve damage, particularly in those without visible damage on MRI (MRI-), suggesting its potential as an early diagnostic tool. The research suggests that assessing spinal cord motion can complement existing diagnostic methods and enable timely surgical treatment, especially in MRI- DCM patients, potentially preventing irreversible cord damage.

Practical Implications

Improved diagnostic workup

Cord motion measurements can serve as a promising additional biomarker to enhance clinical evaluation, especially for MRI- DCM patients.

Timely surgical treatment

Early detection of increased cord motion can enable proactive surgical intervention in a disease stage preceding irreversible cord damage and clinical deterioration.

Personalized treatment strategies

Integrating cord motion assessment into diagnostic protocols may help tailor treatment approaches based on individual mechanical strain on the spinal cord.

Study Limitations

  • 1
    The smaller number of MRI+ patients may reduce the statistical power.
  • 2
    T2w hyperintensity can reflect both, irreversible tissue scar and reversible edema.
  • 3
    Potential confounders of spinal cord motion measurements (e.g., breathing; blood pressure) were not considered.

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