Spinal Cord Research Help
AboutCategoriesLatest ResearchContact
Subscribe
Spinal Cord Research Help

Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

Quick Links

  • Home
  • About
  • Categories
  • Latest Research
  • Disclaimer

Contact

  • Contact Us
© 2025 Spinal Cord Research Help

All rights reserved.

  1. Home
  2. Research
  3. Spinal Cord Injury
  4. Peripheral Quantitative Computed Tomography: Measurement Sensitivity in Persons With and Without Spinal Cord Injury

Peripheral Quantitative Computed Tomography: Measurement Sensitivity in Persons With and Without Spinal Cord Injury

Arch Phys Med Rehabil, 2006 · DOI: 10.1016/j.apmr.2006.07.257 · Published: October 1, 2006

Spinal Cord InjuryRehabilitationMusculoskeletal Medicine

Simple Explanation

This study investigates the accuracy of bone density measurements using a pQCT scanner in people with and without spinal cord injury (SCI). It looks at how errors in measuring limb length can affect the placement of the scanner and the resulting bone mineral density (BMD) readings. The study found that errors in measuring tibia length can lead to differences in BMD measurements, especially in people with SCI. This is important because it can affect the results of studies that are trying to find ways to prevent bone loss after SCI. The researchers suggest that people who use pQCT scanners should be careful to measure limb length accurately and consistently. They also suggest that studies should consider the potential for error when comparing BMD measurements between different groups of people.

Study Duration
Not specified
Participants
8 able-bodied subjects, 7 men with SCI, and 7 able-bodied age-matched male controls
Evidence Level
Not specified

Key Findings

  • 1
    Absolute BMD error was greater for able-bodied than for SCI subjects (5.87mg/cm3 vs 4.5mg/cm3).
  • 2
    The percentage error in BMD was larger for SCI than able-bodied subjects (4.56% vs 2.23%).
  • 3
    Trabecular BMD generally decreased as the scans moved proximally along the tibia.

Research Summary

The purposes of this study are (1) to determine the error attributable to external measurements of tibia length and (2) to establish the difference in BMD along the distal tibia that may occur as a result of tibia length–measurement errors. We explore the difference in error estimates for people with and without spinal cord injury. We hypothesize that limb-length–measurement error could impact the distal tibia BMD measurements. pQCT slice placement may vary among subjects by as much as 3mm when external measurements of tibia length are used.

Practical Implications

Clinical Practice

Clinical and technical personnel should use consistent methods to determine tibia length and periodically repeat measurements to establish a high level of repeatability.

Research

Future studies should consider the potential source of error when determining the efficacy of interventions to preserve tibia BMD after SCI.

Technology

Interpretation of the tibia endplate should be routinely revisited among all staff performing these measurements to ensure a high level of scan-site accuracy.

Study Limitations

  • 1
    The degree of bone mineral loss sustained by subjects in the present study was less than previous reports performed by using pQCT.
  • 2
    The error associated with limb length is likely to be most important when comparing different populations in a 1-time cross-sectional analysis.
  • 3
    The simultaneous scout view feature may not be available on all pQCT devices.

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury