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  4. Neuromodulation in Spinal Cord Injury Using Transcutaneous Spinal Stimulation—Mapping for a Blood Pressure Response: A Case Series

Neuromodulation in Spinal Cord Injury Using Transcutaneous Spinal Stimulation—Mapping for a Blood Pressure Response: A Case Series

Neurotrauma Reports, 2024 · DOI: 10.1089/neur.2024.0066 · Published: January 1, 2024

Spinal Cord InjuryCardiovascular ScienceNeurology

Simple Explanation

This study explores using transcutaneous spinal cord stimulation (scTS) to improve blood pressure in people with spinal cord injuries. The researchers tested different stimulation locations and found that stimulating the lower back area (lumbosacral region) significantly increased blood pressure. This suggests that targeting the lumbosacral region with scTS could be a way to help people with spinal cord injuries better regulate their blood pressure.

Study Duration
Not specified
Participants
8 males with chronic cervical SCI
Evidence Level
Level 4: Case Series

Key Findings

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    Stimulation of the lumbosacral vertebrae region (L1/2, S1/2, and also including T11/12) significantly elevated BP, unlike cervical or upper thoracic stimulation.
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    The observed trend remained consistent across different participants, highlighting the promising role of lumbosacral stimulation in neuromodulating BP.
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    Data on HR were limited, as it was only partially recorded compared with SBP and DBP.

Research Summary

The study investigated the hemodynamic effects of scTS applied at different vertebral locations in individuals with chronic cervical SCI. Lumbosacral stimulation (T11/12, L1/2, S1/2) consistently elevated blood pressure compared to cervical or upper thoracic stimulation. The findings suggest that lumbosacral stimulation may be a promising approach for neuromodulating blood pressure in SCI patients.

Practical Implications

Targeted Therapy Development

The study supports the development of targeted scTS therapies for blood pressure regulation in SCI, specifically focusing on the lumbosacral region.

Mapping Protocol Improvement

The findings can refine mapping protocols for scTS-CV, guiding electrode placement to optimize blood pressure responses.

Personalized Stimulation Strategies

The need for personalization is reinforced, suggesting customized stimulation parameters based on individual anatomical variations.

Study Limitations

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