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  4. Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury

Natural History of Isolated Below-Knee Vein Thrombosis in Patients with Spinal Cord Injury

Healthcare, 2021 · DOI: https://doi.org/10.3390/healthcare9070861 · Published: July 8, 2021

Spinal Cord InjuryCardiovascular ScienceRehabilitation

Simple Explanation

This study investigates the natural progression of blood clots in the lower legs (below-knee deep vein thrombosis, BKDVT) in Asian patients with spinal cord injuries. Typically, serial imaging is recommended, but there's limited research on this specific group. The researchers reviewed data from patients with spinal cord injuries who developed BKDVT. They tracked whether the clots worsened (propagated), disappeared, or remained stable, with or without the use of anticoagulant medications. The findings suggest that in Asian patients with spinal cord injuries, BKDVT has a favorable natural history, with a low risk of worsening. The authors suggest serial imaging might be sufficient instead of immediate anticoagulation.

Study Duration
2016 to 2020
Participants
27 patients with below-the-knee deep vein thrombosis and spinal cord injury
Evidence Level
Retrospective study

Key Findings

  • 1
    None of the patients experienced proximal propagation of BKDVT, meaning the clots did not spread to the upper leg veins.
  • 2
    The disappearance of BKDVT was not significantly different between patients treated with and without non-vitamin K antagonist oral anticoagulants (NOACs).
  • 3
    The study suggests a low overall risk of deep vein thrombosis in Asian patients with spinal cord injury, with 64% of screened patients showing no DVT.

Research Summary

This retrospective study evaluated the natural course of below-knee deep vein thrombosis (BKDVT) in Asian patients with spinal cord injury. It compared outcomes in patients treated with and without anticoagulants. The study found that BKDVT in this population has a low risk of proximal propagation, and anticoagulant treatment did not significantly affect the rate of BKDVT disappearance. The authors recommend considering serial imaging over routine anticoagulant therapy for BKDVT in Asian patients with spinal cord injury, given the low risk of venous thromboembolism in this population.

Practical Implications

Treatment Strategy

The findings suggest that Asian patients with spinal cord injury and BKDVT might not require immediate anticoagulant therapy and could be managed with serial imaging.

Thromboprophylaxis Guidelines

Current thromboprophylaxis guidelines, largely based on Western populations, may need to be re-evaluated for Asian patients with spinal cord injuries due to the lower incidence of VTE.

Risk Assessment

Clinicians should consider race and individual risk factors when determining the appropriate treatment for BKDVT in patients with spinal cord injury.

Study Limitations

  • 1
    Small sample size
  • 2
    Lack of pulmonary embolism evaluation
  • 3
    Retrospective design

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