Mesenchymal Stem Cell-Conditioned Medium Promotes Functional Recovery Following Spinal Cord Injury: A Systematic Review and Meta-analysis

This study investigates the use of mesenchymal stem cell-derived conditioned media (MSC-CM) as a potential treatment for spinal cord injury (SCI) in animal models. Conditioned media may be a desirable alternative to cell therapy. The research focuses on whether MSC-CM can improve movement after SCI, offering a possible solution without the limitations of directly transplanting stem cells. MSC-CM may be a desirable alternative for MSCs in the treatment of SCI, since it does not have the limitations of MSCs. A meta-analysis was performed to consolidate the findings of multiple studies, aiming to provide a clearer understanding of MSC-CM's effectiveness in promoting motor recovery after SCI. Thus, the present systematic review and meta-analysis aims to investigate the efficacy of MSC-CM transplantation in the treatment motor deteriorations in ani-

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  MSC-CM administration in SCI animal models promotes motor recovery, indicating a potential therapeutic effect. MSC-CM administration in SCI animal models promotes motor recovery
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  The efficacy of MSC-CM treatment significantly increases when administered in doses higher than 120 μL. The efficacy of this treatment strategy significantly increases at doses higher than 120 μL.
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  Subgroup analysis identified antibiotic administration, delivery amount, delivery type, and follow-up time as potential sources of heterogeneity between studies. antibiotic administration, delivery amount, delivery type, and follow-up time were the possible sources of heterogeneity.