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  4. Massive Edema of the Lower Limbs in Patients after Spinal Cord Injury—One Picture, Different Diagnoses

Massive Edema of the Lower Limbs in Patients after Spinal Cord Injury—One Picture, Different Diagnoses

International Journal of Environmental Research and Public Health, 2021 · DOI: https://doi.org/10.3390/ijerph18084219 · Published: April 16, 2021

Spinal Cord InjuryCardiovascular ScienceRehabilitation

Simple Explanation

This paper discusses the challenges in diagnosing the cause of leg swelling in patients with spinal cord injuries (SCI). Because SCI patients often have a loss of pain sensation, diagnosing the cause of edema can be difficult. The paper presents four cases of patients with SCI who experienced massive leg swelling due to different underlying conditions, including deep vein thrombosis (DVT), intramuscular hematomas (IHs), heterotopic ossification (HO), and bone fractures. Each of these conditions can be difficult to differentiate in SCI patients. The study emphasizes the importance of careful and continuous observation of edema in SCI patients, as the cause of edema may change over time. Additionally, diagnostic tools, such as ultrasound, can aid in identifying the underlying causes of edema, especially when pain sensation is impaired.

Study Duration
Not specified
Participants
Four case studies of patients with spinal cord injury
Evidence Level
Level 4, Case Series

Key Findings

  • 1
    Lower-limb edema in SCI patients can be caused by various pathologies, including DVT, intramuscular hematomas, heterotopic ossification, and fractures.
  • 2
    Elevated D-dimer levels are common in SCI patients, making it difficult to use this test as the sole indicator of DVT.
  • 3
    Careful observation of edema evolution is crucial, as the onset of new symptoms may indicate a different cause of edema from what was previously established.

Research Summary

This paper reviews pathologies leading to lower-limb edema in SCI patients, highlighting diagnostic difficulties due to sensory loss. It presents four case studies of patients with massive leg edemas at different times after SCI. The cases include DVT, intramuscular hematomas, heterotopic ossification, and humeral bone fractures. The authors emphasize careful observation of edema evolution to detect changes in etiology. The paper concludes that DUS is a valuable tool, but CT or X-ray should be used if DVT or hematoma are not confirmed to check for HO or fractures.

Practical Implications

Differential Diagnosis

Clinicians should consider a wide range of potential causes beyond DVT when evaluating lower-limb edema in SCI patients.

Diagnostic Approach

Relying solely on D-dimer levels for DVT diagnosis in SCI patients is unreliable; imaging techniques like DUS, CT, and X-ray are essential.

Monitoring and Vigilance

Close monitoring of edema evolution and patient symptoms is crucial to identify changes in etiology and guide appropriate management strategies.

Study Limitations

  • 1
    Small sample size (four cases)
  • 2
    Lack of a controlled study design
  • 3
    Limited generalizability due to the specific patient population (SCI)

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