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  4. Longitudinal changes in body composition and metabolic profile between exercise clinical trials in men with chronic spinal cord injury

Longitudinal changes in body composition and metabolic profile between exercise clinical trials in men with chronic spinal cord injury

The Journal of Spinal Cord Medicine, 2016 · DOI: 10.1080/10790268.2016.1157970 · Published: January 1, 2016

Spinal Cord InjuryPhysiologyRehabilitation

Simple Explanation

This study looked at how body composition and metabolism change in men with spinal cord injuries after they stop exercising. Researchers followed men who had participated in exercise trials and compared them to a control group to see if previous exercise affected later measurements. The study found that the positive effects of exercise, like increased muscle mass, faded after about 2.5 years of stopping the exercise program.

Study Duration
2.5 years
Participants
11 men with motor complete SCI
Evidence Level
Longitudinal design

Key Findings

  • 1
    Thigh circumference increased after exercise and remained greater than baseline, but leg lean mass increased following exercise and decreased in the follow-up visit.
  • 2
    Percentage trunk and total body fat mass increased in the follow-up visit.
  • 3
    Basal metabolic rate significantly decreased following the exercise interventions.

Research Summary

The study investigated the longitudinal effects of exercise cessation on body composition and metabolic profiles in men with chronic spinal cord injury (SCI). Following a 2.5-year washout period after an exercise trial, no significant differences were found between the exercise and control groups in body composition or metabolic variables. Exercise training was effective in increasing leg lean mass and decreasing percentage fat mass, but these benefits regressed after 2.5 years of exercise cessation.

Practical Implications

Clinical Trial Design

A 2.5-year gap is sufficient to washout the effects of previous exercise interventions on subsequent clinical trials.

Exercise Maintenance

Continuous exercise interventions are needed to ensure long-term compliance and avoid loss of lean mass and increased fat mass with aging.

Reduced Exercise Frequency

Following an exercise routine, reduced exercise frequency (e.g., once a week) may maintain gains in body composition and metabolic profiles.

Study Limitations

  • 1
    Data collected from three different clinical trials may introduce errors.
  • 2
    Changes in participants' physical or medical status could influence outcomes.
  • 3
    Failure to capture data earlier than two years post-cessation of exercise.

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