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  4. Intermittent theta burst stimulation modulates biceps brachii corticomotor excitability in individuals with tetraplegia

Intermittent theta burst stimulation modulates biceps brachii corticomotor excitability in individuals with tetraplegia

Journal of NeuroEngineering and Rehabilitation, 2022 · DOI: https://doi.org/10.1186/s12984-022-01049-9 · Published: July 6, 2022

Spinal Cord InjuryNeurologyNeurorehabilitation

Simple Explanation

This study investigates the use of intermittent theta burst stimulation (iTBS), a type of brain stimulation, to improve the connection between the brain and biceps muscle in people with tetraplegia (spinal cord injury affecting all four limbs). The researchers compared the effects of iTBS on muscle excitability in individuals with spinal cord injury (SCI) and those without. They measured muscle responses before and after iTBS. The study found that iTBS increased muscle excitability in individuals with SCI, but not in those without SCI. This suggests iTBS may be a useful tool to enhance rehabilitation outcomes in individuals with tetraplegia.

Study Duration
Not specified
Participants
10 individuals with low cervical SCI (C5-C8) and ten nonimpaired individuals
Evidence Level
Not specified

Key Findings

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    Active iTBS increased normalized motor evoked potentials (nMEPs) over time in individuals with SCI, but not nonimpaired individuals.
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    The amplitude of nMEPs were correlated with the biceps corticomotor conductance potential.
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    Individuals with SCI exhibit a more homogeneous facilitatory response to iTBS targeting the biceps than nonimpaired individuals.

Research Summary

This study evaluated the impact of intermittent theta burst stimulation (iTBS) on the corticomotor excitability of the biceps brachii in individuals with tetraplegia compared to nonimpaired individuals. The results indicated that iTBS increased corticomotor excitability in the biceps of individuals with SCI, but not in nonimpaired individuals, suggesting a potential benefit for motor rehabilitation in tetraplegia. Corticomotor conductance potential could be used as a predictive measure of an individual’s responsiveness to iTBS.

Practical Implications

Rehabilitation Potential

iTBS may be a useful adjunct to physical therapy for motor rehabilitation in individuals with tetraplegia by increasing corticomotor excitability of the biceps brachii.

Predictive Biomarker

Corticomotor conductance potential may serve as a predictive measure to identify individuals who are more likely to respond positively to iTBS therapy.

Targeted Therapy

Further research is needed to understand how muscle target and injury level influence the effects of iTBS, allowing for more targeted and effective therapeutic interventions.

Study Limitations

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