Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury

Spinal cord injuries are difficult to treat because the central nervous system does not regenerate well. Stem cell therapies offer promise by replacing lost cells and promoting regeneration. Using stem cells derived from induced pluripotent stem cells (iPSCs) overcomes ethical concerns associated with using fetal or embryonic stem cells. iPSC-derived neural stem cells (NSCs) can be generated from a patient's own cells, reducing the risk of immune rejection after transplantation into the injured spinal cord.

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  iPSC-derived NSCs can differentiate into neurons, astrocytes, and oligodendrocytes after transplantation into animal models of SCI.
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  Some studies have shown functional improvements following iPSC-derived NSC transplantation, while others have not.
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  iPSC-derived NSCs have the potential to promote neuronal relay formation, remyelination, and neuroprotection in the injured spinal cord.