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  4. Functional recovery of a 41-year-old quadriplegic spinal cord injury patient following multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells: a case report

Functional recovery of a 41-year-old quadriplegic spinal cord injury patient following multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells: a case report

Front. Transplant., 2023 · DOI: 10.3389/frtra.2023.1287508 · Published: December 7, 2023

Spinal Cord InjuryRegenerative Medicine

Simple Explanation

This study presents the case of a 41-year-old male with a spinal cord injury who received multiple infusions of his own stem cells derived from fat tissue. Over a period of about 2.5 years, the patient received 34 infusions, which led to significant improvements in his quality of life. The patient's motor and sensory functions improved, as demonstrated by electromyography and nerve conduction velocity studies, and no serious adverse events were reported during the treatment.

Study Duration
∼2.5 years
Participants
A 41-year-old quadriplegic male
Evidence Level
Case Report

Key Findings

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    The patient experienced significant improvements in quality-of-life, as demonstrated by substantial improvements in SCIM-III scores.
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    Electromyography/nerve conduction velocity (EMG/NCV) studies showed improvements in the patient’s motor and sensory function.
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    Multiple intravenous infusions of autologous HB-adMSCs for treatment of SCI demonstrated significant enhancements in the patient’s neurological function.

Research Summary

This case report describes the functional recovery of a 41-year-old quadriplegic spinal cord injury patient following multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells. The patient received 34 recurrent infusions of 200 million cells each over a period of approximately 2.5 years, resulting in significant improvements in quality-of-life and SCIM-III scores. Improvements in motor and sensory function were observed through EMG/NCV studies, and no serious adverse events were reported, suggesting that HB-adMSC therapy may offer a relatively safe and non-invasive treatment option for patients with SCI.

Practical Implications

Therapeutic Potential

Autologous HB-adMSC therapy may offer a safe and non-invasive treatment option for improving neurological function in SCI patients.

Quality of Life Improvement

Recurrent administration of intravenous infusions of autologous HB-adMSCs resulted in improved SCIM-III scores, reflecting clinically relevant functional improvements.

Further Research

Future clinical trials with a larger sample size and randomized, placebo-controlled study design should be conducted to validate the findings of this study.

Study Limitations

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